دورية أكاديمية
Mitochondrial dysfunction and NDUFS3: Insights from a PINK1 B9 Drosophila model in Parkinson's disease pathogenesis.
| العنوان: | Mitochondrial dysfunction and NDUFS3: Insights from a PINK1 B9 Drosophila model in Parkinson's disease pathogenesis. |
|---|---|
| المؤلفون: | Fan X; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541004, China., Tang Y; Clinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China., Wei Z; Guangxi Key Laboratory of Liver Disease Immunity and Metabolism, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China., Shi F; Laboratory of Neuroscience, Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guilin 541004, China., Cui Y; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541004, China., Li Q; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541004, China; Clinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China; Laboratory of Neuroscience, Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guilin 541004, China. Electronic address: qhli1999@163.com. |
| المصدر: | Neuroscience letters [Neurosci Lett] 2024 Sep 14; Vol. 839, pp. 137917. Date of Electronic Publication: 2024 Aug 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Animals, Genetically Modified* , Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Parkinson Disease*/genetics , Parkinson Disease*/metabolism , Drosophila melanogaster* , Mitochondria*/metabolism , Mitochondria*/genetics , Disease Models, Animal* , Electron Transport Complex I*/metabolism , Electron Transport Complex I*/genetics, Animals ; NADH Dehydrogenase/genetics ; NADH Dehydrogenase/metabolism ; RNA Interference ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Oxidative Stress/genetics |
| مستخلص: | PTEN-induced kinase1 (PINK1) mutation is the main cause of autosomal recessive inheritance and early-onset Parkinson's disease. Mitochondrial respiratory chain complex I (CI) functional impairment has been considered to be an important factor in the pathogenesis of PD in recent years. In addition, NDUFS3 (nicotinamide adenine dinucleotide deoxylase iron-thionein 3) is one of the core subunits of mitochondrial CI. Therefore, this study explored the role of NDUFS3 gene in PINK1 B9 transgenic Drosophila and its possible related mechanisms. In this study, the PD transgenic Drosophila model of MHC-Gal4/UAS system was selected to specifically activate the expression of PINK1 B9 gene in the chest muscle tissue of Drosophila melanogaster. NDUFS3 RNAi interference was used to interfere with PINK1 B9 transgenic Drosophila melanogaster and its effect on PD transgenic flies was studied. The results suggest that down-regulation of NDUFS3 gene expression may have a protective effect on PINK1 B9 transgenic Drosophila melanogaster, and we speculate that down-regulation of NDUFS3 gene expression to reduce oxidative stress and restore mitochondrial function may be related to mitochondrial stress response. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Drosophila melanogaster; Mitochondrial dysfunction; NDUFS3 RNAi; Oxidative stress; PINK1 mutation |
| المشرفين على المادة: | 0 (Drosophila Proteins) EC 7.1.1.2 (Electron Transport Complex I) EC 2.7.11.1 (PINK1 protein, Drosophila) EC 1.6.99.3 (NADH Dehydrogenase) EC 2.7.11.1 (Protein Serine-Threonine Kinases) |
| تواريخ الأحداث: | Date Created: 20240805 Date Completed: 20240908 Latest Revision: 20240909 |
| رمز التحديث: | 20240909 |
| DOI: | 10.1016/j.neulet.2024.137917 |
| PMID: | 39102941 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7972 |
|---|---|
| DOI: | 10.1016/j.neulet.2024.137917 |