Diagnostic accuracy of an uncorrected native T1 mapping sequence for liver fibrosis and inflammation in autoimmune hepatitis: a prospective study using histopathology as reference standard.

التفاصيل البيبلوغرافية
العنوان:	Diagnostic accuracy of an uncorrected native T1 mapping sequence for liver fibrosis and inflammation in autoimmune hepatitis: a prospective study using histopathology as reference standard.
المؤلفون:	Gomes NBN; Grupo Fleury, São Paulo, Brazil. nataliaborgesnunes@gmail.com.; Department of Diagnostic Imaging, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Vila Clementino Rua Napoleão de Barros, 800, São Paulo, SP, 04024-000, Brazil. nataliaborgesnunes@gmail.com., Torres US; Grupo Fleury, São Paulo, Brazil.; Department of Diagnostic Imaging, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Vila Clementino Rua Napoleão de Barros, 800, São Paulo, SP, 04024-000, Brazil., Caiado AHM; Grupo Fleury, São Paulo, Brazil., Fucuta PS; Hospital de Base, Faculdade de Medicina de São José do Rio Preto (FAMERP), São Paulo, Brazil., Ferraz MLCG; Department of Gastroenterology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., D'Ippolito G; Grupo Fleury, São Paulo, Brazil.; Department of Diagnostic Imaging, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Vila Clementino Rua Napoleão de Barros, 800, São Paulo, SP, 04024-000, Brazil.
المصدر:	La Radiologia medica [Radiol Med] 2024 Aug 06. Date of Electronic Publication: 2024 Aug 06.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Milan Country of Publication: Italy NLM ID: 0177625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1826-6983 (Electronic) Linking ISSN: 00338362 NLM ISO Abbreviation: Radiol Med Subsets: MEDLINE
أسماء مطبوعة:	Publication: Milan : Springer Milan Original Publication: Torino [etc.] Minerva medica.
مستخلص:	Purpose: There is an unmet clinical need for non-invasive imaging biomarkers that could replace liver biopsy in the management of patients with autoimmune hepatitis (AIH). In this study, we sought to evaluate the diagnostic accuracy of a simple uncorrected, non-contrast T1 mapping for detecting fibrosis and inflammation in AIH patients using histopathology as a reference standard. Material and Methods: Over 3 years, 33 patients with AIH were prospectively studied using a multiparametric liver MRI protocol which included T1 mapping. Biopsies were performed up to 3 months before imaging, and a standardized histopathological score for fibrosis (F0-F4) and inflammatory activity (PPA0-4) was used as a reference. Statistical analysis included independent t test, Mann-Whitney U-test, and ROC (receiver operating characteristic) analysis. Results: T1 mapping values were significantly higher in patients with advanced fibrosis (F0-2 vs. F3-4; p < 0.015), significant fibrosis (F0-1 vs. F2-4; p < 0.005), and significant inflammatory activity (PPA 0-1 vs. PPA 2-4 p = 0.048). Moreover, the technique demonstrated a good diagnostic performance in detecting significant (AUC 0.856) and advanced fibrosis (AUC 0.835), as well as significant inflammatory activity (AUC 0.763). Conclusion: A rapid, simple, uncorrected, non-contrast T1 mapping sequence showed satisfactory diagnostic performance in comparison with histopathology for detecting significant tissue inflammation and fibrosis in AIH patients, being a potential non-invasive imaging biomarker for monitoring disease activity in such individuals. (© 2024. Italian Society of Medical Radiology.)
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معلومات مُعتمدة:	NP-312 Grupo Fleury; 20884 / IIR-BR-2018-578 Bayer Foundation; 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 150055/2019-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة:	Keywords: Autoimmune hepatitis; Chronic hepatitis; Diagnostic imaging; Multiparametric magnetic resonance imaging
تواريخ الأحداث:	Date Created: 20240806 Latest Revision: 20240806
رمز التحديث:	20240806
DOI:	10.1007/s11547-024-01863-2
PMID:	39106024
قاعدة البيانات:	MEDLINE

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تدمد:	1826-6983
DOI:	10.1007/s11547-024-01863-2