دورية أكاديمية
Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study.
| العنوان: | Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study. |
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| المؤلفون: | Filiz M; Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Gulhane School of Medicine, Ankara, Turkey., Erdem H; Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Gulhane School of Medicine, Ankara, Turkey., Ankarali H; Department of Biostatistics and Medical Informatics, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey., Puca E; Department of Infectious Diseases, University Hospital Center 'Mother Teresa', Tirana, Albania., Ruch Y; Department of Infectious Diseases, Strasbourg University Hospital, Nouvel Hôpital Civil, Strasbourg, France., Santos L; Infectious Diseases Department, Centro Hospitalar São João, Portugal and Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Fasciana T; Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D'Alessandro, University of Palermo, Palermo, Italy., Giammanco AM; Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D'Alessandro, University of Palermo, Palermo, Italy., Ghanem-Zoubi N; Institute of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel., Argemi X; GCS Almaviva Santé, Clinique Axium, Aix-en-Provence, France., Hansmann Y; Department of Infectious Diseases, Strasbourg University Hospital, Nouvel Hôpital Civil, Strasbourg, France., Guner R; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey., Tonziello G; Clinical & Research Department for Infectious Diseases, National Institute for Infectious Diseases 'Lazzaro Spallanzani', IRCCS, Via Portuense, Rome, Italy., Mazzucotelli JP; Department of Cardiovascular Surgery, Strasbourg University Hospital, Nouvel Hôpital Civil, Strasbourg, France., Como N; Service of Infectious Disease, UHC Tirana, Albania., Kose S; Department of Infectious Diseases and Clinical Microbiology, Tepecik Training and Research Hospital, Izmir, Turkey., Batirel A; Department of Infectious Diseases and Clinical Microbiology, Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey., Inan A; Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey., Tulek N; Department of Microbiology, Atilim University, School of Medicine, Ankara, Turkey., Pekok AU; Department of Infectious Diseases and Clinical Microbiology, Pendik Medical Park Hospital, Istanbul, Turkey., Khan EA; Shifa International Hospital and Shifa Tameer-e-Millat University, Islamabad, Pakistan., Iyisoy A; Department of Cardiology, Health Sciences University, Gulhane School of Medicine, Ankara, Turkey., Meric-Koc M; Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University School of Medicine, Istanbul, Turkey., Kaya-Kalem A; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey., Martins PP; Infectious Diseases Department, Centro Hospitalar São João, Portugal and Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Hasanoglu I; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey., Silva-Pinto A; Infectious Diseases Department, Centro Hospitalar São João, Portugal and Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Oztoprak N; Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey., Duro R; Infectious Diseases Department, Centro Hospitalar São João, Portugal and Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Almajid F; Department of Medicine, Infectious Diseases Division, King Saud University Hospital, Riyadh, Saudi Arabia., Dogan M; Department of Infectious Diseases and Clinical Microbiology, Corlu State Hospital, Tekirdag, Turkey., Dauby N; Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre 322 rue Haute - 1000 Brussels, Université libre de Bruxelles (ULB), Belgium., Gunst JD; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Tekin R; Department of Infectious Diseases and Clinical Microbiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey., Konopnicki D; Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre 322 rue Haute - 1000 Brussels, Université libre de Bruxelles (ULB), Belgium., Petrosillo N; Clinical & Research Department for Infectious Diseases, National Institute for Infectious Diseases 'Lazzaro Spallanzani', IRCCS, Via Portuense, Rome, Italy., Bozkurt I; Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey., Al Ramahi JW; Department of Infectious Diseases, The University of Jordan, School of Medicine, Amman, Jordan., Popescu C; Dr Victor Babes Clinical Hospital of Infectious and Tropical Disease, Bucharest, Romania., Balkan II; Department of Infectious Diseases and Clinical Microbiology, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Ozer-Balin S; Department of Infectious Diseases and Clinical Microbiology, Firat University Faculty of Medicine, Elazig, Turkey., Zupanc TL; Department of Infectious Diseases, UMC Ljubljana, Ljubljana, Slovenia., Cascio A; Department of Health Promotion Sciences and Mother and Child Care 'G. D'Alessandro', University of Palermo, Palermo, Italy., Dumitru IM; Ovidius University of Constanta, Clinical Infectious Diseases Hospital, Constanta, Romania., Erdem A; Department of Pathology, Kecioren Training and Research Hospital, Ankara, Turkey., Ersoz G; Department of Infectious Diseases and Clinical Microbiology, Mersin University School of Medicine, Mersin, Turkey., Tasbakan M; Department of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, Izmir, Turkey., Ajamieh OA; Department of Infectious Diseases, The University of Jordan, School of Medicine, Amman, Jordan., Sirmatel F; Department of Infectious Disease and Clinical Microbiology, Izzet Baysal University School of Medicine, Bolu, Turkey., Florescu S; Dr Victor Babes Clinical Hospital of Infectious and Tropical Disease, Bucharest, Romania., Gulsun S; Department of Infectious Diseases and Clinical Microbiology, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey., Ozkaya HD; Department of Infectious Diseases and Clinical Microbiology, Bakircay University, Cigli Training and Research Hospital, Izmir, Turkey., Sari S; Department of Intensive Care Unit, Turkey Advanced Specialty Education and Research Hospital, Ankara, Turkey., Tosun S; Department of Infectious Diseases and Clinical Microbiology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey., Avci M; Department of Infectious Disease and Clinical Microbiology, Usak University School of Medicine, Usak, Turkey., Cag Y; Department of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey., Celebi G; Department of Infectious Diseases and Clinical Microbiology, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey., Sagmak-Tartar A; Department of Infectious Diseases and Clinical Microbiology, Firat University Faculty of Medicine, Elazig, Turkey., Karakus S; Department of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey., Sener A; Department of Infectious Diseases and Clinical Microbiology, Onsekiz Mart University School of Medicine, Canakkale, Turkey., Dedej A; Department of Nephrology, American Hospital, Tirana, Albania., Oncu S; Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes University School of Medicine, Aydin, Turkey., Del Vecchio RF; Infectious Diseases Department, Umberto I Public Hospital, Siracusa, Italy., Ozturk-Engin D; Department of Infectious Diseases and Clinical Microbiology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey., Agalar C; Department of Infectious Diseases and Clinical Microbiology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey. |
| المصدر: | New microbes and new infections [New Microbes New Infect] 2024 Jul 14; Vol. 60-61, pp. 101453. Date of Electronic Publication: 2024 Jul 14 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 101624750 Publication Model: eCollection Cited Medium: Print ISSN: 2052-2975 (Print) Linking ISSN: 20522975 NLM ISO Abbreviation: New Microbes New Infect Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Elsevier Original Publication: [Hoboken, New Jersey] : John Wiley & Sons, 2013- |
| مستخلص: | Background: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI). The study analysing one of the largest case series ever reported was conducted across 41 centers in 13 countries. We analysed the database to determine the predictors of BCNE using univariate and logistic regression analyses. Results: Blood cultures were negative in 101 (11.65 %) of 867 patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95 % CI 0.963-0.987, p < 0.001). Additionally, factors such as rheumatic heart disease (OR 2.036, 95 % CI 0.970-4.276, p = 0.049), aortic stenosis (OR 3.066, 95 % CI 1.564-6.010, p = 0.001), mitral regurgitation (OR 1.693, 95 % CI 1.012-2.833, p = 0.045), and prosthetic valves (OR 2.539, 95 % CI 1.599-4.031, p < 0.001) are associated with higher likelihoods of negative blood cultures. Our model can predict whether a patient falls into the culture-negative or culture-positive groups with a threshold of 0.104 (AUC±SE = 0.707 ± 0.027). The final model demonstrates a sensitivity of 70.3 % and a specificity of 57.0 %. Conclusion: Caution should be exercised when diagnosing endocarditis in patients with concurrent cardiac disorders, particularly in younger cases. Competing Interests: None to declare. (© 2024 Published by Elsevier Ltd.) |
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| فهرسة مساهمة: | Keywords: Blood culture negative endocarditis; Cardiac disorders; Infective endocarditis; Prosthetic valves; Rheumatic heart disease |
| تواريخ الأحداث: | Date Created: 20240807 Latest Revision: 20240808 |
| رمز التحديث: | 20240808 |
| مُعرف محوري في PubMed: | PMC11301364 |
| DOI: | 10.1016/j.nmni.2024.101453 |
| PMID: | 39109072 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2052-2975 |
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| DOI: | 10.1016/j.nmni.2024.101453 |