دورية أكاديمية
Incidence and prevalence of primary biliary cholangitis in the Netherlands - A nationwide cohort study.
| العنوان: | Incidence and prevalence of primary biliary cholangitis in the Netherlands - A nationwide cohort study. |
|---|---|
| المؤلفون: | de Veer RC; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands., van Hooff MCB; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands., Werner E; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands., Beuers U; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands., Drenth JPH; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands., Cuperus FJC; Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands., van Hoek B; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands., Veldt BJ; Department of Gastroenterology and Hepatology Reinier de Graaf Gasthuis, Delft, the Netherlands., Klemt-Kropp M; Department of Gastroenterology and Hepatology, Noordwest Ziekenhuisgroep, Alkmaar, the Netherlands., van Meer S; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands., Verdonk RC; Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, the Netherlands., Flink HJ; Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, the Netherlands., Vrolijk JM; Department of Gastroenterology and Hepatology, Rijnstate, Arnhem, the Netherlands., Gevers TJG; Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands., Ponsioen CY; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands., Ter Borg MJ; Department of Gastroenterology and Hepatology, Maxima Medical Center, Eindhoven, the Netherlands., Soufidi K; Department of Gastroenterology and Hepatology, Zuyderland Medical Center, Heerlen, the Netherlands., Boersma F; Department of Gastroenterology and Hepatology, Gelre Hospitals, Apeldoorn-Zutphen, the Netherlands., de Jonge HJM; Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, Den Bosch, the Netherlands., Wolfhagen FHJ; Department of Gastroenterology and Hepatology, Albert Schweitzer Hospital, Dordrecht, the Netherlands., Baak LC; Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands., Onderwater SL; Department of Gastroenterology and Hepatology, Diakonessenhuis, Utrecht, the Netherlands., van Bergeijk JD; Department of Gastroenterology and Hepatology, Hospital De Gelderse Vallei, Ede, the Netherlands., van Putten PG; Department of Gastroenterology and Hepatology, Medical Center Leeuwarden, Leeuwarden, the Netherlands., de Bruin GJ; Department of Gastroenterology and Hepatology, Tergooi Hospital, Hilversum-Blaricum, the Netherlands., Adang RPR; Department of Gastroenterology and Hepatology, VieCuri, Venlo, the Netherlands., Aparicio-Pages MN; Department of Gastroenterology and Hepatology, Canisius/Wilhemina Hospital, Nijmegen, the Netherlands., de Boer W; Department of Gastroenterology and Hepatology, Bernhoven, Uden, the Netherlands., Borg FT; Department of Gastroenterology and Hepatology, Deventer Hospital, Deventer, the Netherlands., van Soest H; Department of Gastroenterology and Hepatology, Medical Center Haaglanden, Den Haag, the Netherlands., Janssen HLA; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Gastroenterology and Hepatology, Toronto Centre for Liver Disease, University of Toronto, Ontario, Canada., Hansen BE; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Erler NS; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., van der Meer AJ; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands. |
| مؤلفون مشاركون: | Dutch PBC Study Group |
| المصدر: | JHEP reports : innovation in hepatology [JHEP Rep] 2024 Jun 06; Vol. 6 (8), pp. 101132. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2019]- |
| مستخلص: | Background & Aims: Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS). Methods: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time. Results: On the 1 st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged <45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, p <0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, p <0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those <45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, p <0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, p <0.001). Conclusions: In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences. Impact and Implications: This nationwide Dutch primary biliary cholangitis (PBC) Cohort Study, including all hospitals in the Netherlands, showed that the incidence and prevalence of PBC have increased over the last decade. The age-dependent PBC incidence rate differed for males (highest risk ≥65 years) and females (highest risk between 45 and 65 years), which may be related to a difference in the timing of exposure to environmental triggers of PBC. The largest increase in PBC prevalence over time was observed in the population aged ≥65 years, which may have implications for the use of second-line therapies. These results therefore indicate that further studies are needed to elaborate on the advantages and disadvantages of add-on therapies in the elderly population. (© 2024 The Authors.) |
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| فهرسة مساهمة: | Investigator: S Abraham; RP Adang; H Aktas; YA Alderlieste; MN Aparicio-Pages; LBC Baak; MA Baven-Pronk; AS van der Beek; FC Bekkering; JD van Bergeijk; U Beuers; M Beukema; W de Boer; F Boersma; K Boonstra; F Ter Borg; MJ Ter Borg; PC Ter Borg; GJ de Bruin; PJ Bus; DL Cahen; M Cazemier; FJ Cuperus; LJ van Dam; MJ Denters; JP Drenth; LS Epping; NS Erler; HJ Flink; PW Friederich; NF van Gerven; TJ Gevers; BE Hansen; SJ van den Hazel; B van Hoek; MC van Hooff; DM Hotho; H Janssen; HJ de Jonge; MC Jurgens; JNV Kemenade; MJ Kerbert-Dreteler; M Klemt-Kropp; IC Konings; S de Kort; EM Kuiper; JP Kuyvenhoven; AJ van der Meer; S van Meer; SL Onderwater; LH Oterdoom; CY Ponsioen; PG van Putten; JE van Rooij; R Roomer; J Schmidt-Böhmer; S Schmittgens; TC Schreuder; JS Nicolaas; H van Soest; K Soufidi; SH van Stiphout; HH Thio; MM Tielemans; S Vandebosch; RC de Veer; BJ Veldt; RC Verdonk; J Marleen de Vree; E de Vries; A Vrieze; JM Vrolijk; LA van der Waaij; E Werner; U de Wit; FH Wolfhagen Keywords: Incidence; Prevalence; Primary biliary cholangitis |
| تواريخ الأحداث: | Date Created: 20240808 Latest Revision: 20240809 |
| رمز التحديث: | 20240809 |
| مُعرف محوري في PubMed: | PMC11304051 |
| DOI: | 10.1016/j.jhepr.2024.101132 |
| PMID: | 39113899 |
| قاعدة البيانات: | MEDLINE |
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