دورية أكاديمية
Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites.
| العنوان: | Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites. |
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| المؤلفون: | Siegel SV; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, 0811, Australia., Trimarsanto H; Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, 0811, Australia.; Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Jakarta, 10430, Indonesia., Amato R; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Murie K; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Taylor AR; Institut Pasteur, University de Paris, Infectious Disease Epidemiology and Analytics Unit, Paris, France., Sutanto E; Exeins Health Initiative, Jakarta Selatan, 12870, Indonesia., Kleinecke M; Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, 0811, Australia., Whitton G; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Watson JA; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LJ, UK.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet, W.1, Dist.5, Ho Chi Minh City, Vietnam., Imwong M; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Assefa A; Ethiopian Public Health Institute, Addis Ababa, Ethiopia.; Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Rahim AG; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.; Afghan International Islamic University, Kabul, Afghanistan., Nguyen HC; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet, W.1, Dist.5, Ho Chi Minh City, Vietnam., Tran TH; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet, W.1, Dist.5, Ho Chi Minh City, Vietnam., Green JA; Formerly GlaxoSmithKline, Brentford, UK., Koh GCKW; Department of Infectious Diseases, Northwick Park Hospital, Harrow, UK., White NJ; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LJ, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand., Day N; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LJ, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand., Kwiatkowski DP; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Rayner JC; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Price RN; Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, 0811, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LJ, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand., Auburn S; Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, 0811, Australia. Sarah.Auburn@Menzies.edu.au.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LJ, UK. Sarah.Auburn@Menzies.edu.au. |
| المصدر: | Nature communications [Nat Commun] 2024 Aug 08; Vol. 15 (1), pp. 6757. Date of Electronic Publication: 2024 Aug 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Plasmodium vivax*/genetics , Malaria, Vivax*/parasitology , Malaria, Vivax*/epidemiology , Recurrence*, Humans ; Haplotypes/genetics ; Polymorphism, Single Nucleotide ; Genome, Protozoan/genetics ; Genotype |
| مستخلص: | Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of antimalarial efficacy and transmission. Recurrent infections may arise from activation of dormant liver stages (relapse), blood-stage treatment failure (recrudescence) or reinfection. Molecular inference of familial relatedness (identity-by-descent or IBD) can help resolve the probable origin of recurrences. As whole genome sequencing of P. vivax remains challenging, targeted genotyping methods are needed for scalability. We describe a P. vivax marker discovery framework to identify and select panels of microhaplotypes (multi-allelic markers within small, amplifiable segments of the genome) that can accurately capture IBD. We evaluate panels of 50-250 microhaplotypes discovered in a global set of 615 P. vivax genomes. A candidate global 100-microhaplotype panel exhibits high marker diversity in the Asia-Pacific, Latin America and horn of Africa (median H (© 2024. The Author(s).) |
| التعليقات: | Update of: medRxiv. 2023 Mar 16:2023.03.13.23287179. doi: 10.1101/2023.03.13.23287179. (PMID: 36993192) |
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| معلومات مُعتمدة: | R01AI137154 U.S. Department of Health & Human Services | National Institutes of Health (NIH); R01 AI137154 United States AI NIAID NIH HHS; 206194/Z17/Z Wellcome Trust (Wellcome); APP2001083 Department of Health | National Health and Medical Research Council (NHMRC); United Kingdom WT_ Wellcome Trust; INV-043618 Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation); 204911 United Kingdom WT_ Wellcome Trust; OPP1054404 Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation); 206194 United Kingdom WT_ Wellcome Trust; ICRG GR071614MA Wellcome Trust (Wellcome) |
| تواريخ الأحداث: | Date Created: 20240808 Date Completed: 20240808 Latest Revision: 20240813 |
| رمز التحديث: | 20240813 |
| مُعرف محوري في PubMed: | PMC11310204 |
| DOI: | 10.1038/s41467-024-51015-3 |
| PMID: | 39117628 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-51015-3 |