دورية أكاديمية
Assessing the impact of short-term Lugol's solution on toxic nodular thyroid disease: a pre-post-intervention study.
| العنوان: | Assessing the impact of short-term Lugol's solution on toxic nodular thyroid disease: a pre-post-intervention study. |
|---|---|
| المؤلفون: | Hedberg F; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Cramon PK; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Endocrinology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Bränström R; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden., Falhammar H; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Calissendorff J; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jul 25; Vol. 15, pp. 1420154. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024). |
| نوع المنشور: | Clinical Trial, Phase III; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Goiter, Nodular*/drug therapy , Goiter, Nodular*/blood , Iodides*/administration & dosage, Aged ; Female ; Humans ; Male ; Middle Aged ; Hyperthyroidism/drug therapy ; Quality of Life ; Thyroid Hormones/blood |
| مستخلص: | Purpose: Preoperative iodine therapy in toxic nodular goiter (TNG) is discouraged as iodine may cause aggravation of hyperthyroidism. We aimed to examine if a short course of iodine treatment is safe to administer in TNG. Methods: Patients with TNG (n=20) and subclinical to mild hyperthyroidism (free (f)T4 <30 pmol/L) without complicating illnesses were included in this pre-post-intervention study at Karolinska University Hospital. All participants received Lugol's solution 5%, three oral drops thrice daily for 10 days. Heart rate, TSH, fT4, fT3 concentrations were collected before (day 0) and after treatment (day 10). Thyroid hormone concentrations were also measured at two time points during treatment to discover aggravations of hyperthyroidism. ThyPRO39se, a quality-of-life questionnaire, was filled out day 0 and day 10. Differences in heart rate, thyroid hormone concentrations, and quality-of-life before and after treatment were compared. Adverse reactions were reported. Results: The median age was 63.5 years. Female to male ratio 19:1. FT4 and fT3 concentrations decreased (both p <0.001), and TSH concentration increased ( p <0.001) after 10 days of treatment. There was no difference in heart rate. No aggravations of thyrotoxicosis were noticed in any of the participants. ThyPRO39se scores improved on three scales, including hyperthyroid symptoms, while the remaining scale scores were unchanged. Mild and transient symptoms related to or possibly related to treatment were observed in six participants. Conclusion: A short course of Lugol's solution improved thyroid hormone concentrations, reduced patient-reported hyperthyroid symptoms and was safe in TNG. Lugol's solution might be an option for preoperative treatment in TNG. Clinical Trial Registration: https://www.clinicaltrials.gov, identifier NCT04856488. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Hedberg, Cramon, Bränström, Falhammar and Calissendorff.) |
| References: | Eur J Endocrinol. 2010 Jan;162(1):161-7. (PMID: 19797502) Qual Life Res. 2015 Mar;24(3):769-80. (PMID: 25194574) Ann N Y Acad Sci. 2019 Jun;1446(1):44-65. (PMID: 30891786) Lancet. 1952 Jul 5;2(6723):5-10. (PMID: 14939804) Ann Intern Med. 1962 Apr;56:577-89. (PMID: 13926662) Thyroid. 2023 Mar;33(3):273-275. (PMID: 36792929) J Clin Endocrinol Metab. 2007 Jun;92(6):2182-9. (PMID: 17389702) J Clin Endocrinol Metab. 1975 Jan;40(1):33-6. (PMID: 1112879) Food Nutr Res. 2016 Jun 08;60:31969. (PMID: 27283870) World J Surg. 2016 Mar;40(3):505-9. (PMID: 26546192) Ann Med Surg (Lond). 2016 Jun 16;9:53-7. (PMID: 27408715) Surgery. 2018 Jan;163(1):68-72. (PMID: 29108701) J Clin Endocrinol Metab. 1956 Jan;16(1):130-7. (PMID: 13278387) Eur Thyroid J. 2018 Aug;7(4):167-186. (PMID: 30283735) Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):618-24. (PMID: 21892078) Endocrine. 2017 Dec;58(3):467-473. (PMID: 29075974) Clin Sci. 1964 Dec;27:399-405. (PMID: 14236777) Eur Thyroid J. 2021 Jul;10(4):269-284. (PMID: 34395299) Am J Surg. 2017 Apr;213(4):805-809. (PMID: 27769543) Thyroid. 1996 Apr;6(2):107-10. (PMID: 8733880) Horm Res. 1996;45(3-5):142-7. (PMID: 8964573) Metabolism. 1956 Nov;5(6 Part 1):682-96. (PMID: 13378034) Endocrinol Metab Clin North Am. 1998 Mar;27(1):151-68. (PMID: 9534034) Thyroid. 2015 Oct;25(10):1069-79. (PMID: 26214034) Ann Med Surg (Lond). 2022 Aug 28;81:104487. (PMID: 36147169) Thyroid. 2016 Oct;26(10):1343-1421. (PMID: 27521067) Thyroid. 2015 May;25(5):471-7. (PMID: 25744578) Br J Surg. 1985 Jan;72(1):45-7. (PMID: 3967130) J Clin Invest. 1970 Jan;49(1):78-86. (PMID: 5409810) |
| فهرسة مساهمة: | Keywords: Lugol; hyperthyroidism; iodine; thyrotoxicosis; toxic adenoma; toxic nodular goiter |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04856488 |
| المشرفين على المادة: | 0 (Iodides) T66M6Y3KSA (Lugol's solution) 0 (Thyroid Hormones) |
| تواريخ الأحداث: | Date Created: 20240809 Date Completed: 20240809 Latest Revision: 20240814 |
| رمز التحديث: | 20240814 |
| مُعرف محوري في PubMed: | PMC11306062 |
| DOI: | 10.3389/fendo.2024.1420154 |
| PMID: | 39119004 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
|---|---|
| DOI: | 10.3389/fendo.2024.1420154 |