دورية أكاديمية
أعرض في EDS

Frequency of seropositive celiac disease and hypothyroidism among children and adolescents with congenital heart disease: A case-control study.

التفاصيل البيبلوغرافية
العنوان: Frequency of seropositive celiac disease and hypothyroidism among children and adolescents with congenital heart disease: A case-control study.
المؤلفون: Edraki MR; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Kerachi AJ; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Yazdani N; Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran., Honar N; Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. honarn@sums.ac.ir.; Department of Pediatric Gastroenterology, Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. honarn@sums.ac.ir., Dehghani R; School of Medicine, Bam University of Medical Sciences, Bam, Iran., Afshar Z; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Dehghani M; Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran., Amoozgar H; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
المصدر: BMC pediatrics [BMC Pediatr] 2024 Aug 09; Vol. 24 (1), pp. 513. Date of Electronic Publication: 2024 Aug 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967804 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2431 (Electronic) Linking ISSN: 14712431 NLM ISO Abbreviation: BMC Pediatr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Celiac Disease*/blood , Celiac Disease*/complications , Heart Defects, Congenital*/blood , Heart Defects, Congenital*/complications , Hypothyroidism*/blood , Hypothyroidism*/epidemiology , Hypothyroidism*/complications, Humans ; Case-Control Studies ; Male ; Female ; Child ; Adolescent ; Child, Preschool ; Prospective Studies ; Infant ; Autoantibodies/blood ; Iran/epidemiology ; Prevalence ; Thyrotropin/blood
مستخلص: Background: The prevalence of celiac disease (CD) and hypothyroidism exhibit significant variation in different studies among patients with congenital heart disease (CHD). This study evaluated the frequency of laboratory test abnormalities in children and adolescents with CHD in Shiraz, Iran.
Methods: This prospective case-control study was conducted on 223 children and adolescents with CHD and healthy individuals referred to the heart clinic affiliated with Shiraz University of Medical Sciences between February 2019 and December 2021. They were classified into case and control groups. Blood tests were performed for total IgA antibody, anti-tissue transglutaminase IgA antibody (anti-TTG Ab), T4, and thyroid stimulating hormone (TSH) and anti-thyroid peroxidase antibodies in serum, along with transthoracic echocardiography. Likewise, demographic characteristics of patients, including age, sex, weight, height, and body mass index (BMI), were recorded. Also, anti-TTG Ab levels were compared among CHD patients according to cyanosis status, gender, age (above and below five years), and BMI (under and over 18.5).
Results: Ninety-eight CHD patients and 100 healthy individuals with an average age of 5.32 ± 4.05 years (1-18 years) were examined. In children with CHD, atrial septal defect (27%), ventricular septal defect (20%), and tetralogy of Fallot (13%) were the most prevalent disorders. Only one CHD patient had an anti-TTG Ab level of 16.6 unit/mL, considered borderline for seropositive CD diagnosis. There was no difference in anti-TTG Ab levels between age (above and below five years), BMI (under and over 18.5), cyanosis status, and gender groups. Seven CHD patients had high TSH levels, three had cyanotic CHD, and one had Down syndrome. The TSH levels and non-autoimmune hypothyroidism were significantly higher in CHD patients than in normal subjects (p < 0.05).
Conclusions: According to the results of this study, the serum level of TSH and prevalence of non-autoimmune hypothyroidism were higher in patients with CHD than in normal subjects, but the serum level of anti-TTG Ab was not different between the two groups.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Adolescence; Celiac Disease; Child; Congenital heart defects; Hypothyroidism
المشرفين على المادة: 0 (Autoantibodies)
9002-71-5 (Thyrotropin)
تواريخ الأحداث: Date Created: 20240809 Date Completed: 20240810 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11312714
DOI: 10.1186/s12887-023-04283-9
PMID: 39123137
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2431
DOI:10.1186/s12887-023-04283-9