دورية أكاديمية
أعرض في EDS

Presepsin in Human Milk Is Delivery Mode and Gender Dependent.

التفاصيل البيبلوغرافية
العنوان: Presepsin in Human Milk Is Delivery Mode and Gender Dependent.
المؤلفون: D'Adamo E; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Peila C; Neonatology Unit, Department of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy., Strozzi M; Department of Pediatrics and Neonatology, Cardinal Massaia Hospital, 14100 Asti, Italy., Barolo R; Neonatology Unit, Department of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy., Maconi A; Department of Maternal, Fetal and Neonatal Medicine, ASO SS Antonio, Biagio and C. Arrigo, 15121 Alessandria, Italy., Nanni A; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Botondi V; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Coscia A; Neonatology Unit, Department of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy., Bertino E; Neonatology Unit, Department of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy., Gazzolo F; Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy., Abdelhameed AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Conte M; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Picone S; Neonatal Intensive Care Unit, Policlinico Casilino, 00169 Rome, Italy., D'Andrea M; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Lizzi M; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Quarta MT; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy., Gazzolo D; Neonatal Intensive Care Unit, 'G. D'Annunzio' University, 66100 Chieti, Italy.
المصدر: Nutrients [Nutrients] 2024 Aug 03; Vol. 16 (15). Date of Electronic Publication: 2024 Aug 03.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Milk, Human*/chemistry , Peptide Fragments*/analysis , Lipopolysaccharide Receptors*/metabolism, Humans ; Female ; Prospective Studies ; Infant, Newborn ; Case-Control Studies ; Male ; Infant, Premature ; Adult ; Biomarkers/analysis ; Delivery, Obstetric ; Sex Factors ; Pregnancy
مستخلص: Breast milk (BM) is a unique food due to its nutritional composition and anti-inflammatory characteristics. Evidence has emerged on the role of Presepsin (PSEP) as a reliable marker of early sepsis diagnosis. In the present study, we aimed to investigate the measurability of PSEP in BM according to different maturation stages (colostrum, C; transition, Tr; and mature milks, Mt) and corrected for delivery mode and gender. We conducted a multicenter prospective case-control study in women who had delivered 22 term (T) and 22 preterm (PT) infants. A total of 44 human milk samples were collected and stored at -80 °C. BM PSEP (pg/mL) levels were measured by using a rapid chemiluminescent enzyme immunoassay. PSEP was detected in all samples analyzed. Higher ( p < 0.05) BM PSEP concentrations were observed in the PT compared to the T infants. According to the grade of maturation, higher ( p < 0.05) levels of PSEP in C compared to Tr and Mt milks were observed in the whole study population. The BM subtypes' degrees of maturation were delivery mode and gender dependent. We found that PSEP at high concentrations supports its antimicrobial action both in PT and T infants. These results open the door to further studies investigating the role of PSEP.
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معلومات مُعتمدة: 3/2019 I COLORI DELLA VITA FOUNDATION and DANONE; RSPD2024R750 King Saud University
فهرسة مساهمة: Keywords: breastmilk; newborn; nutrition; presepsin; preterm; sCD14
المشرفين على المادة: 0 (Peptide Fragments)
0 (presepsin protein, human)
0 (Lipopolysaccharide Receptors)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11313726
DOI: 10.3390/nu16152554
PMID: 39125434
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16152554