دورية أكاديمية
أعرض في EDS

Study of microRNAs in Gingival Crevicular Fluid as Periodontal Diseases Biomarkers: Systematic Review.

التفاصيل البيبلوغرافية
العنوان: Study of microRNAs in Gingival Crevicular Fluid as Periodontal Diseases Biomarkers: Systematic Review.
المؤلفون: Cosín-Villanueva M; Department of Stomatology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain., Almiñana-Pastor PJ; Department of Stomatology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain., García-Giménez JL; Biomedical Research Institute INCLIVA, 46010 Valencia, Spain.; Consortium Center for Biomedical Network Research on Rare Diseases, CIBERER-ISCIII, 46010 Valencia, Spain.; Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain., López-Roldán A; Department of Stomatology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 29; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 29.
نوع المنشور: Journal Article; Systematic Review; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Gingival Crevicular Fluid*/metabolism , MicroRNAs*/genetics , Biomarkers* , Periodontal Diseases*/diagnosis , Periodontal Diseases*/genetics , Periodontal Diseases*/metabolism, Humans
مستخلص: Aim: The aim of this review was to identify the microRNAs (miRNAs) present in gingival crevicular fluid (GCF) that can be used as biomarkers for the diagnosis of periodontal diseases, and to determine which of them has a higher diagnostic yield for periodontitis.
Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42024544648). The Pubmed, Scopus, Cochrane Library, Embase, Web of Science, and Google Scholar databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs in GCF. The methodological quality of the articles was measured with the Newcastle-Ottawa Scale.
Results: A total of 3222 references were identified in the initial literature search, and 16 articles were finally included in the review. The design of the studies was heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-200b-3p and miR-146a.
Conclusions: the miRNAs most studied are miR-146a, miR-200b, miR-223, miR-23a, and miR-203, and all of them except miR-203 have an acceptable diagnostic plausibility for periodontitis.
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فهرسة مساهمة: Keywords: epigenetic; microRNA; periodontal diseases; periodontitis
المشرفين على المادة: 0 (MicroRNAs)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240814
رمز التحديث: 20240815
مُعرف محوري في PubMed: PMC11311819
DOI: 10.3390/ijms25158274
PMID: 39125843
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25158274