دورية أكاديمية
أعرض في EDS

Photoinactivation of Mycobacterium tuberculosis and Mycobacterium smegmatis by Near-Infrared Radiation Using a Trehalose-Conjugated Heptamethine Cyanine.

التفاصيل البيبلوغرافية
العنوان: Photoinactivation of Mycobacterium tuberculosis and Mycobacterium smegmatis by Near-Infrared Radiation Using a Trehalose-Conjugated Heptamethine Cyanine.
المؤلفون: Kozobkova NV; A.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia., Samtsov MP; A.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus., Lugovski AP; A.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus., Bel'ko NV; A.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus., Tarasov DS; A.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus., Kaprelyants AS; A.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia., Savitsky AP; A.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia., Shleeva MO; A.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 04; Vol. 25 (15). Date of Electronic Publication: 2024 Aug 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Mycobacterium smegmatis*/drug effects , Mycobacterium smegmatis*/radiation effects , Infrared Rays* , Trehalose*/pharmacology , Trehalose*/chemistry , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/radiation effects , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemistry, Carbocyanines/chemistry ; Carbocyanines/pharmacology ; Photochemotherapy/methods
مستخلص: The spread of multidrug-resistant mycobacterium strains requires the development of new approaches to combat diseases caused by these pathogens. For that, photodynamic inactivation (PDI) is a promising approach. In this study, a tricarbocyanine (TCC) is used for the first time as a near-infrared (740 nm) activatable PDI photosensitizer to kill mycobacteria with deep light penetration. For better targeting, a novel tricarbocyanine dye functionalized with two trehalose units (TCC2Tre) is developed. The photodynamic effect of the conjugates against mycobacteria, including Mycobacterium tuberculosis , is evaluated. Under irradiation, TCC2Tre causes more effective killing of mycobacteria compared to the photosensitizer without trehalose conjugation, with 99.99% dead vegetative cells of M. tuberculosis and M. smegmatis . In addition, effective photoinactivation of dormant forms of M. smegmatis is observed after incubation with TCC2Tre. Mycobacteria treated with TCC2Tre are more sensitive to 740 nm light than the Gram-positive Micrococcus luteus and the Gram-negative Escherichia coli . For the first time, this study demonstrates the proof of principle of in vitro PDI of mycobacteria including the fast-growing M. smegmatis and the slow-growing M. tuberculosis using near-infrared activatable photosensitizers conjugated with trehalose. These findings are useful for the development of new efficient alternatives to antibiotic therapy.
References: Molecules. 2020 Nov 10;25(22):. (PMID: 33182751)
J Bacteriol. 2023 Jan 26;205(1):e0033722. (PMID: 36598232)
RSC Adv. 2021;2021(12):7037-7042. (PMID: 34336191)
J Biol Chem. 2004 Jul 9;279(28):28835-43. (PMID: 15102847)
Chembiochem. 2023 Sep 15;24(18):e202300177. (PMID: 37132365)
Clin Epidemiol Glob Health. 2022 May-Jun;15:101031. (PMID: 35372717)
Mikrobiologiia. 2011 Sep-Oct;80(5):625-36. (PMID: 22168006)
JACS Au. 2023 Mar 27;3(4):1017-1028. (PMID: 37124305)
Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9687-9695. (PMID: 31713670)
Angew Chem Int Ed Engl. 2023 Jan 9;62(2):e202213563. (PMID: 36346622)
Methods Mol Biol. 2021;2314:385-398. (PMID: 34235664)
Bull Exp Biol Med. 2023 Jul;175(3):367-370. (PMID: 37563535)
Emerg Infect Dis. 2013 Mar;19(3):449-55. (PMID: 23622714)
Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2307625120. (PMID: 37603751)
Biochemistry (Mosc). 2023 Jan;88(Suppl 1):S52-S74. (PMID: 37069114)
J Appl Microbiol. 2010 Nov;109(5):1660-7. (PMID: 20602657)
Nat Chem Biol. 2011 Apr;7(4):228-35. (PMID: 21378984)
Chem Rev. 2018 Dec 12;118(23):11457-11517. (PMID: 30507165)
Curr Opin Chem Biol. 2021 Dec;65:57-65. (PMID: 34216933)
J Clin Transl Res. 2015 Dec 1;1(3):140-167. (PMID: 30873451)
JACS Au. 2021 Jul 26;1(9):1368-1379. (PMID: 34604847)
Methods Cell Biol. 1994;45:107-25. (PMID: 7707982)
Int J Syst Evol Microbiol. 2005 Jan;55(Pt 1):293-302. (PMID: 15653890)
Microbiology (Reading). 2014 Aug;160(Pt 8):1547-1570. (PMID: 24858083)
Appl Microbiol Biotechnol. 2021 May;105(10):4099-4109. (PMID: 33997929)
ACS Omega. 2020 Feb 14;5(7):3661-3669. (PMID: 32118181)
J Am Chem Soc. 2020 Sep 9;142(36):15259-15264. (PMID: 32813512)
Sci Rep. 2024 Jan 8;14(1):846. (PMID: 38191600)
ACS Cent Sci. 2019 Apr 24;5(4):644-650. (PMID: 31041384)
Front Med (Lausanne). 2021 May 12;8:642609. (PMID: 34055830)
Dermatol Clin. 2015 Jul;33(3):563-77. (PMID: 26143432)
PLoS Pathog. 2021 Feb 1;17(2):e1009262. (PMID: 33524021)
J Biol Chem. 2019 Oct 25;294(43):15711-15723. (PMID: 31471317)
معلومات مُعتمدة: 24-15-00221 the Russian Science Foundation
فهرسة مساهمة: Keywords: Mycobacterium tuberculosis; antibacterial photodynamic inactivation; dormant mycobacteria; mycobacteria; trehalose; tricarbocyanine dye
المشرفين على المادة: B8WCK70T7I (Trehalose)
0 (Photosensitizing Agents)
0 (Carbocyanines)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11313374
DOI: 10.3390/ijms25158505
PMID: 39126073
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25158505