دورية أكاديمية
Acoustofluidic-based therapeutic apheresis system.
| العنوان: | Acoustofluidic-based therapeutic apheresis system. |
|---|---|
| المؤلفون: | Wu M; School of Mechanical Engineering, Dalian University of Technology, Dalian, Liaoning, P.R. China.; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Ma Z; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Xu X; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Lu B; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Gu Y; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Yoon J; Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, 27708, USA., Xia J; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Ma Z; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Upreti N; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Anwar IJ; Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, 27708, USA., Knechtle SJ; Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, 27708, USA., T Chambers E; Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, 27708, USA., Kwun J; Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, 27708, USA. jean.kwun@duke.edu., Lee LP; Renal Division and Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Harvard University, Brigham and Women's Hospital, Boston, MA, 02115, USA. lplee@bwh.harvard.edu.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, 94720, USA. lplee@bwh.harvard.edu.; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA. lplee@bwh.harvard.edu.; Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Korea. lplee@bwh.harvard.edu.; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Korea. lplee@bwh.harvard.edu., Huang TJ; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA. tony.huang@duke.edu. |
| المصدر: | Nature communications [Nat Commun] 2024 Aug 10; Vol. 15 (1), pp. 6854. Date of Electronic Publication: 2024 Aug 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Blood Component Removal*/instrumentation , Blood Component Removal*/methods , Plasmapheresis*/instrumentation , Plasmapheresis*/methods, Animals ; Mice ; Humans ; Lab-On-A-Chip Devices ; Female ; Acoustics/instrumentation |
| مستخلص: | Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients. (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.) |
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| معلومات مُعتمدة: | R44HL140800 Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.); U19AI131471 Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.); R01HD103727 Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.); R01 GM132603 United States GM NIGMS NIH HHS; U19 AI131471 United States AI NIAID NIH HHS; R44 HL140800 United States HL NHLBI NIH HHS; R01GM132603 Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.); R01 HD103727 United States HD NICHD NIH HHS |
| تواريخ الأحداث: | Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240923 |
| رمز التحديث: | 20240923 |
| مُعرف محوري في PubMed: | PMC11316742 |
| DOI: | 10.1038/s41467-024-50053-1 |
| PMID: | 39127732 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-50053-1 |