دورية أكاديمية
أعرض في EDS

Serum Cystatin C levels increase with increasing visceral fat area in patients with type 2 diabetes mellitus.

التفاصيل البيبلوغرافية
العنوان: Serum Cystatin C levels increase with increasing visceral fat area in patients with type 2 diabetes mellitus.
المؤلفون: Cong X; Department of Endocrinology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, China., Chen X; Department of Endocrinology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, China., Shen Q; Department of Endocrinology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, China., Wu Y; Department of Endocrinology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, China., Wang Q; Department of Endocrinology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, China., Chen L; Department of Endocrinology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, China. szlei2004@163.com.
المصدر: Scientific reports [Sci Rep] 2024 Aug 11; Vol. 14 (1), pp. 18638. Date of Electronic Publication: 2024 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Cystatin C*/blood , Diabetes Mellitus, Type 2*/blood , Intra-Abdominal Fat*/metabolism, Humans ; Male ; Middle Aged ; Female ; Insulin Resistance ; Aged ; Body Mass Index ; Waist Circumference ; Adult ; Biomarkers/blood
مستخلص: The present study aimed to explore the association between serum cystatin C (Cys-C) levels and visceral fat area (VFA) in patients with type 2 diabetes mellitus (T2DM). A total of 208 previously diagnosed T2DM patients who visited our hospital from September 2019 to December 2021 were included and divided into three groups based on tertiles of Cys-C levels, namely, Groups C1, C2, and C3. The clinical data of the subjects were collected, biochemical parameters such as Cys-C levels were determined, and bioelectrical impedance analysis was applied to determine the VFA and subcutaneous fat area (SFA). The VFA in Group C1 was lower than that in Groups C2 and C3 (all P < 0.05), with no significant difference in VFA between Groups C2 and C3 (P > 0.05). Spearman's correlation analysis revealed that the serum Cys-C level was positively correlated with age, VFA, SFA, insulin resistance index, waist circumference, body mass index, systolic blood pressure, serum creatinine level, and blood uric acid level (r = 0.543, 0.353, 0.168, 0.148, 0.365, 0.264, 0.25, 0.497, and 0.155, respectively; P < 0.05) and negatively correlated with glycated haemoglobin levels (r = -0.175, P < 0.05). Univariate linear regression analysis revealed that VFA was positively correlated with the Cys-C level (β = 0.002, 95% CI = 0.001-0.003, P < 0.05), with an increase of 0.002 mg/L in the Cys-C level for each 1 cm 2 increase in VFA. Further multivariate linear regression analysis was performed with the serum Cys-C level as the dependent variable and age, VFA, SFA, insulin resistance (HOMA-IR), WC, BMI, SBP, Cr, UA, and HbA1c as the independent variables. The results suggested that VFA was positively correlated with serum Cys-C level (β = 0.001, 95% CI = 0.000-0.002, P < 0.05), with serum Cys-C levels increasing by 0.001 mg/L for every 1 cm 2 increase in VFA. Using a VFA ≥ 100 cm 2 as the criterion for visceral obesity, ROC analysis revealed that the Cys-C level was a better predictor of visceral obesity, with an area under the ROC curve (AUC) of 0.701 (95% CI = 0.631-0.771, P < 0.05), an optimal cut-off of 0.905 mg/L, and a sensitivity and specificity of 58.3% and 75.2%, respectively. The results suggested that the serum Cys-C level was correlated with the VFA in patients with T2DM and that Cys-C may play a vital role in T2DM patients with visceral obesity.
(© 2024. The Author(s).)
References: Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31. (PMID: 31862745)
Biomolecules. 2020 Dec 12;10(12):. (PMID: 33322719)
Med Clin North Am. 2018 Jan;102(1):65-85. (PMID: 29156188)
Biochimie. 2010 Nov;92(11):1580-6. (PMID: 20417681)
Hematology. 2020 Dec;25(1):457-463. (PMID: 33250014)
PLoS Med. 2022 Apr 26;19(4):e1003970. (PMID: 35472059)
Front Endocrinol (Lausanne). 2022 Feb 04;13:816201. (PMID: 35185798)
Nephrol Dial Transplant. 2013 Jul;28(7):1820-9. (PMID: 23291367)
Nat Rev Endocrinol. 2021 Sep;17(9):534-548. (PMID: 34172940)
Circ J. 2002 Nov;66(11):987-92. (PMID: 12419927)
Mol Cell Endocrinol. 2019 Feb 15;482:28-36. (PMID: 30543877)
Postgrad Med. 2022 Apr;134(3):297-302. (PMID: 35142235)
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C375-C391. (PMID: 33356944)
Indian J Pediatr. 2020 Dec;87(12):991-992. (PMID: 33047256)
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Dec 30;42(6):795-800. (PMID: 33423728)
Nihon Hoshasen Gijutsu Gakkai Zasshi. 2022;78(3):257-262. (PMID: 35314534)
Clin Nephrol. 2004 Aug;62(2):92-6. (PMID: 15356965)
JACC Heart Fail. 2015 Jan;3(1):40-49. (PMID: 25453534)
ESC Heart Fail. 2020 Oct;7(5):2240-2249. (PMID: 32648717)
JAMA Netw Open. 2022 Feb 1;5(2):e2148940. (PMID: 35175342)
Diabetes. 2020 Sep;69(9):1927-1935. (PMID: 32616516)
Ann Vasc Surg. 2021 May;73:244-253. (PMID: 33388409)
Diabetes Res Clin Pract. 2022 Jan;183:109119. (PMID: 34879977)
Indian J Endocrinol Metab. 2020 Jul-Aug;24(4):312-318. (PMID: 33088753)
Diabetes Res Clin Pract. 2018 May;139:43-51. (PMID: 29453992)
J Diabetes Complications. 2023 Aug;37(8):108545. (PMID: 37348180)
J Obes Metab Syndr. 2018 Jun 30;27(2):84-92. (PMID: 31089547)
Saudi J Kidney Dis Transpl. 2019 May-Jun;30(3):648-654. (PMID: 31249229)
Biochimie. 2019 Nov;166:233-250. (PMID: 31071357)
BMC Geriatr. 2021 Apr 28;21(1):282. (PMID: 33910516)
معلومات مُعتمدة: KJXW2021029 Project of Invigorating Healthcare through Science, Technology and Education
فهرسة مساهمة: Keywords: Type 2 Diabetes Mellitus; Cystatin C; Visceral Fat Area; Association
المشرفين على المادة: 0 (Cystatin C)
0 (CST3 protein, human)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240811 Date Completed: 20240811 Latest Revision: 20240814
رمز التحديث: 20240814
مُعرف محوري في PubMed: PMC11317477
DOI: 10.1038/s41598-024-69623-w
PMID: 39128944
قاعدة البيانات: MEDLINE
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