دورية أكاديمية
Ion carrier modulated MRI contrast.
| العنوان: | Ion carrier modulated MRI contrast. |
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| المؤلفون: | Duncan AM; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914., Ellis CM; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914., Levingston H; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914., Kerckhoffs A; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914., Mózes FE; Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Level 0, John Radcliffe Hospital Oxford OX3 9DU UK., Langton MJ; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914., Davis JJ; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914. |
| المصدر: | Chemical science [Chem Sci] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry, [2010]- |
| مستخلص: | An ion-responsive MRI contrast agent based on a POPC liposomal scaffold is generated that displays a large amplitude relaxivity switch. Entrapment of MR active Gd-DOTA within cholesterol-doped, i.e. , membrane rigidified, liposomes dampens the MR response through diminished water exchange across the lipid bilayer. Relaxivity is re-established by integration of ion carriers in the liposome membrane to mediate solvated ion flux. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
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| تواريخ الأحداث: | Date Created: 20240812 Latest Revision: 20240813 |
| رمز التحديث: | 20240813 |
| مُعرف محوري في PubMed: | PMC11310829 |
| DOI: | 10.1039/d3sc03466f |
| PMID: | 39129769 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2041-6520 |
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| DOI: | 10.1039/d3sc03466f |