دورية أكاديمية
أعرض في EDS

Irisin promotes hair growth and hair cycle transition by activating the GSK-3β/β-catenin pathway.

التفاصيل البيبلوغرافية
العنوان: Irisin promotes hair growth and hair cycle transition by activating the GSK-3β/β-catenin pathway.
المؤلفون: Kim Y; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea., Lee JM; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.; Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea., Jang YN; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea., Park AY; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea., Kim SY; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.; Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea., Kim BJ; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.; Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea., Lee JO; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.
المصدر: Experimental dermatology [Exp Dermatol] 2024 Aug; Vol. 33 (8), pp. e15155.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Copenhagen : Munksgaard, c1992-
مواضيع طبية MeSH: Fibronectins*/metabolism , Glycogen Synthase Kinase 3 beta*/metabolism , Wnt Signaling Pathway* , Hair*/growth & development , beta Catenin*/metabolism , Hair Follicle*/growth & development , Hair Follicle*/metabolism , Mice, Inbred C57BL*, Animals ; Humans ; Mice ; Lymphoid Enhancer-Binding Factor 1/metabolism ; Cell Proliferation ; Wnt-5a Protein/metabolism ; Wnt Proteins/metabolism ; Male ; Female ; Proto-Oncogene Proteins
مستخلص: Hair loss affects men and women of all ages. Myokines, which are mainly secreted by skeletal muscles during exercise, have numerous health benefits. VEGF, IGF-1, FGF and irisin are reprehensive myokines. Although VEGF, IGF-1 and FGF are positively associated with hair growth, few studies have researched the effects of irisin on hair growth. Here, we investigated whether irisin promotes hair growth using in vitro, ex vivo and in vivo patch assays, as well as mouse models. We show that irisin increases proliferation, alkaline phosphatase (ALP) activity and mitochondrial membrane potential in human dermal papilla cells (hDPCs). Irisin activated the Wnt/β-catenin signalling pathway, thereby upregulating Wnt5a, Wnt10b and LEF-1, which play an important role in hair growth. Moreover, irisin enhanced human hair shaft elongation. In vivo, patch assays revealed that irisin promotes the generation of new hair follicles, accelerates entry into the anagen phase, and significantly increases hair growth in C57BL/6 mice. However, XAV939, a Wnt/β-catenin signalling inhibitor, suppressed the irisin-mediated increase in hair shaft and hair growth. These results indicate that irisin increases hair growth via the Wnt/β-catenin pathway and highlight its therapeutic potential in hair loss treatment.
(© 2024 The Author(s). Experimental Dermatology published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: National Research Foundation of Korea (NRF)
فهرسة مساهمة: Keywords: Irisin; Wnt/β‐catenin; hair loss; human dermal papilla cells; myokine
المشرفين على المادة: 0 (Fibronectins)
0 (FNDC5 protein, human)
EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
0 (beta Catenin)
0 (Lymphoid Enhancer-Binding Factor 1)
0 (WNT10B protein, human)
0 (Wnt-5a Protein)
0 (LEF1 protein, human)
0 (Wnt Proteins)
0 (FNDC5 protein, mouse)
0 (Wnt10b protein, mouse)
EC 2.7.11.1 (GSK3B protein, human)
0 (CTNNB1 protein, human)
0 (Proto-Oncogene Proteins)
تواريخ الأحداث: Date Created: 20240812 Date Completed: 20240812 Latest Revision: 20240812
رمز التحديث: 20240813
DOI: 10.1111/exd.15155
PMID: 39133009
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0625
DOI:10.1111/exd.15155