دورية أكاديمية
Non-invasive prediction of post-sustained virological response HCC in HCV: A systematic review and meta-analysis.
| العنوان: | Non-invasive prediction of post-sustained virological response HCC in HCV: A systematic review and meta-analysis. |
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| المؤلفون: | Lee HA; Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea., Kim MN; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Liver Center, Severance Hospital, Seoul, Korea., Lee HA; Clinical Trial Center, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea., Choi M; Division of Health Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea., Yu JH; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea., Jin YJ; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea., An J; Department of Gastroenterology and Hepatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea., Chon YE; Department of Internal Medicine, Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea., Kim HY; Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Republic of Korea., Han JW; The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea., Kim SU; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Liver Center, Severance Hospital, Seoul, Korea. |
| المصدر: | Clinical and molecular hepatology [Clin Mol Hepatol] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association for the Study of the Liver Country of Publication: Korea (South) NLM ID: 101586730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2287-285X (Electronic) Linking ISSN: 22872728 NLM ISO Abbreviation: Clin Mol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, Korea : Korean Association for the Study of the Liver |
| مستخلص: | Background: Despite advances in antiviral therapy for hepatitis C virus (HCV) infection, hepatocellular carcinoma (HCC) still develops even after sustained viral response (SVR) in patients with advanced liver fibrosis or cirrhosis. This meta-analysis investigated the predictive performance of transient elastography (TE) and fibrosis 4-index (FIB-4) for the development of HCC after SVR. Methods: We searched PubMed, MEDLINE, EMBASE, and the Cochrane Library for studies examining the predictive performance of these tests in adult patients with HCV. Two authors independently screened the studies' methodological quality and extracted data. Pooled estimates of sensitivity, specificity, and area under the curve (AUC) were calculated for HCC development using random-effects bivariate logit normal and linear-mixed effect models. Results: We included 27 studies (169,911 patients). Meta-analysis of HCC after SVR was possible in nine TE and 15 FIB-4 studies. Regarding the prediction of HCC development after SVR, the pooled AUCs of pre-treatment TE >9.2-13 kPa and FIB-4 >3.25 were 0.79 and 0.73, respectively. TE >8.4-11 kPa and FIB-4 >3.25 measured after SVR, maintained good predictive performance, albeit slightly reduced (pooled AUCs: 0.77 and 0.70, respectively). The identified optimal cut-off value for HCC development after SVR was 12.6 kPa for pre-treatment TE. That of TE measured after the SVR was 11.2 kPa. Conclusion: TE and FIB-4 showed acceptable predictive performance for HCC development in patients with HCV who achieved SVR, underscoring their utility in clinical practice for guiding surveillance strategies. Future studies are needed to validate these findings prospectively and validate their clinical impact. |
| فهرسة مساهمة: | Keywords: fibrosis 4-index; hepatitis C virus; hepatocellular carcinoma; prediction; transient elastography |
| تواريخ الأحداث: | Date Created: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.3350/cmh.2024.0262 |
| PMID: | 39134075 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2287-285X |
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| DOI: | 10.3350/cmh.2024.0262 |