دورية أكاديمية
Comparison of fibroblast growth factor 19 concentrations between dogs with and without gallbladder mucoceles.
| العنوان: | Comparison of fibroblast growth factor 19 concentrations between dogs with and without gallbladder mucoceles. |
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| المؤلفون: | Truong VNY; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.; Veterinary Biomedical Sciences, Seoul National University School of Veterinary Medicine, Seoul, South Korea., Liu CC; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Myers J; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.; Large Animal Clinical Sciences, Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, Texas, USA., Miller M; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.; Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA., Yang A; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.; Assessments, Accountability, and Analytics, Louisiana Department of Education, Baton Rouge, Louisiana, USA., Lee J; Pathobiological Sciences and Louisiana Animal Disease Diagnostic Laboratory, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Welborn N; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Johnston AN; Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA. |
| المصدر: | Journal of veterinary internal medicine [J Vet Intern Med] 2024 Sep-Oct; Vol. 38 (5), pp. 2518-2522. Date of Electronic Publication: 2024 Aug 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Periodicals Country of Publication: United States NLM ID: 8708660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-1676 (Electronic) Linking ISSN: 08916640 NLM ISO Abbreviation: J Vet Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010-> : Malden, MA : Wiley Periodicals Original Publication: Philadelphia : J.B. Lippincott Co., [c1987- |
| مواضيع طبية MeSH: | Dog Diseases*/blood , Dog Diseases*/metabolism , Fibroblast Growth Factors*/blood , Mucocele*/veterinary , Mucocele*/blood , Gallbladder Diseases*/veterinary , Gallbladder Diseases*/blood , Gallbladder Diseases*/metabolism, Animals ; Dogs ; Male ; Female ; Prospective Studies ; Cross-Sectional Studies ; Case-Control Studies |
| مستخلص: | Background: Fibroblast growth factor 19 (FGF19) is an enterohepatic hormone the synthesis of which is stimulated by bile acid activation of the nuclear farnesoid X receptor (FXR) in ileal enterocytes. Increased production of FGF19 downregulates hepatocyte bile acid synthesis and gluconeogenesis, while concurrently upregulating hepatocyte glycogenesis and gallbladder (GB) filling. The physiologic impact of this regulatory cycle is illustrated in cholecystectomized humans, in whom the disturbed meal-related flux of GB bile decreases serum FGF19 concentrations. Objective: Determine if serum FGF19 concentrations are lower in dogs with clinical GB mucoceles (GBMs) than in control dogs. Animals: Seven dogs with GBM diagnosed using abdominal ultrasonography, biochemical markers, and GB histopathology. Forty-two control dogs without gastrointestinal or hepatobiliary disorders also were evaluated. Health status of controls was assessed by physical examination and diagnostic hematologic and biochemical test results. Methods: Prospective cross-sectional study to compare fasting plasma or serum FGF19 concentrations between groups. Concentrations of FGF19 were quantified by a commercially available FGF19 ELISA. Results: Concentrations of FGF19 were significantly lower in dogs with clinical GBM (median, 14.0 pg/mL; range, 12.8-67.2) than in control dogs (median, 145.3 pg/mL; range, 36.5-285.1). Conclusions and Clinical Importance: In dogs, GBM is associated with significantly decreased serum FGF19 concentrations. We speculate that this finding reflects compromised GB contraction and decreased enterohepatic circulation of bile flow. Subnormal FGF19 concentrations may influence bile acid synthesis and hepatic metabolism. (© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.) |
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| معلومات مُعتمدة: | Discover Undergraduate Research Program at Louisiana State University |
| فهرسة مساهمة: | Keywords: canine; cholecystitis; fibroblast growth factor 19; hepatobiliary |
| المشرفين على المادة: | 62031-54-3 (Fibroblast Growth Factors) |
| تواريخ الأحداث: | Date Created: 20240812 Date Completed: 20240925 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| مُعرف محوري في PubMed: | PMC11423440 |
| DOI: | 10.1111/jvim.17165 |
| PMID: | 39134090 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1939-1676 |
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| DOI: | 10.1111/jvim.17165 |