دورية أكاديمية
Autoimmune diseases, autoantibody status and silicosis in a cohort of 1238 workers from the artificial stone benchtop industry.
| العنوان: | Autoimmune diseases, autoantibody status and silicosis in a cohort of 1238 workers from the artificial stone benchtop industry. |
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| المؤلفون: | Tomic D; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia., Hoy RF; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia.; Department of Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australia., Sin J; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia., Jimenez Martin J; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia., Gwini SM; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia., Barnes H; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia.; Department of Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australia., Nikpour M; Department of Medicine, The University of Melbourne Medicine at St Vincent's Hospital, Fitzroy, Victoria, Australia.; Department of Rheumatology, St Vincent's Hospital Melbourne Pty Ltd, Fitzroy, Victoria, Australia., Morrisroe K; Department of Medicine, The University of Melbourne Medicine at St Vincent's Hospital, Fitzroy, Victoria, Australia.; Department of Rheumatology, St Vincent's Hospital Melbourne Pty Ltd, Fitzroy, Victoria, Australia., Lim YZ; Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia., Walker-Bone K; Centre for Occupational and Environmental Health, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia Karen.Walker-Bone@Monash.edu.; MRC Versus Arthritis Centre for Musculoskeletal Health and Work, University of Southampton MRC Lifecourse Epidemiology Centre, Southampton, UK. |
| المصدر: | Occupational and environmental medicine [Occup Environ Med] 2024 Aug 29; Vol. 81 (8), pp. 388-394. Date of Electronic Publication: 2024 Aug 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9422759 Publication Model: Electronic Cited Medium: Internet ISSN: 1470-7926 (Electronic) Linking ISSN: 13510711 NLM ISO Abbreviation: Occup Environ Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Pub. Group, c1994- |
| مواضيع طبية MeSH: | Silicosis*/epidemiology , Silicosis*/immunology , Silicosis*/blood , Silicosis*/etiology , Occupational Exposure*/adverse effects , Autoimmune Diseases*/epidemiology , Autoimmune Diseases*/immunology , Autoantibodies*/blood , Silicon Dioxide*/adverse effects, Humans ; Male ; Female ; Middle Aged ; Adult ; Victoria/epidemiology ; Cohort Studies ; Antibodies, Antinuclear/blood ; Occupational Diseases/epidemiology ; Occupational Diseases/immunology ; Occupational Diseases/blood ; Occupational Diseases/etiology ; Prevalence ; Aged ; Rheumatoid Factor/blood ; Rheumatoid Factor/immunology |
| مستخلص: | Objectives: Autoimmune disorders are multifactorial but occupational exposures have long been implicated, including respirable crystalline silica (RCS). A modern epidemic of silicosis is emerging internationally, associated with dry processing of engineered stone with high (>90%) RCS content. We aimed to investigate the prevalence of clinical autoimmune disease and common autoantibodies in exposed workers. Methods: Stone benchtop industry workers in Victoria, Australia were offered free screening for silicosis and related disorders. Symptoms or diagnoses of autoimmune disease were evaluated by questionnaire and blood tests taken for rheumatoid factor (RF), antinuclear antibodies (ANAs) and extractable nuclear antigens (ENAs). Results: Among 1238 workers (93.3% male) screened from 2019 to 2021, 0.9% were confirmed with autoimmune disease. Among those without clinical disease, 24.6% had detectable ANAs (93.5% male), 4.6% detectable ENAs and 2.6% were positive for RF. Silicosis was diagnosed in 253 workers (24.3% of those with diagnostic information available). Of those with ANA readings, 54 (6.6%) had ANA titre >1:320. The likelihood of positive autoantibodies increased with age; smoking; higher exposure to RCS and silicosis diagnosis. Conclusion: The proportion of workers with detectable ANAs or ENAs was considerably higher than the 5%-9% expected in the general population. Some of the antibodies detected (eg, Scl-70, CENPB) have high sensitivity and specificity for systemic sclerosis. Long-term follow-up will be needed to estimate incidence. Rheumatologists should explore occupational history in new cases of autoimmune disease. Screening for autoimmune disease is indicated in workers exposed to RCS as these individuals need specialised management and may be entitled to compensation. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.) |
| فهرسة مساهمة: | Keywords: Autoimmune Diseases; Silicosis |
| المشرفين على المادة: | 0 (Autoantibodies) 7631-86-9 (Silicon Dioxide) 0 (Antibodies, Antinuclear) 9009-79-4 (Rheumatoid Factor) |
| تواريخ الأحداث: | Date Created: 20240812 Date Completed: 20240829 Latest Revision: 20240829 |
| رمز التحديث: | 20240830 |
| DOI: | 10.1136/oemed-2024-109526 |
| PMID: | 39134395 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1470-7926 |
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| DOI: | 10.1136/oemed-2024-109526 |