دورية أكاديمية
Exploring the crosstalk molecular mechanisms between IgA nephropathy and Sjögren's syndrome based on comprehensive bioinformatics and immunohistochemical analyses.
| العنوان: | Exploring the crosstalk molecular mechanisms between IgA nephropathy and Sjögren's syndrome based on comprehensive bioinformatics and immunohistochemical analyses. |
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| المؤلفون: | He P; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Wei L; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Zhang R; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Zhao J; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Zhang Y; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Huang L; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Bai X; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Ning X; Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. ningxx01@fmmu.edu.cn., Sun S; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. sunshiren@medmail.com.cn. |
| المصدر: | Clinical and experimental medicine [Clin Exp Med] 2024 Aug 13; Vol. 24 (1), pp. 188. Date of Electronic Publication: 2024 Aug 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milano, Italy: Springer-Verlag Italia, c2001- |
| مواضيع طبية MeSH: | Glomerulonephritis, IGA*/genetics , Glomerulonephritis, IGA*/metabolism , Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/immunology , Sjogren's Syndrome*/genetics , Sjogren's Syndrome*/immunology , Sjogren's Syndrome*/metabolism , Computational Biology* , Protein Interaction Maps* , Immunohistochemistry*, Humans ; Gene Expression Profiling ; Gene Regulatory Networks |
| مستخلص: | IgA nephropathy (IgAN) and Sjogren's syndrome (SS) are two autoimmune diseases with undetermined etiology and related to abnormal activation of lymphocytes. This study aims to explore the crucial genes, pathways and immune cells between IgAN and SS. Gene expression profiles of IgAN and SS were obtained from the Gene Expression Omnibus and Nephroseq data. Differentially expressed gene (DEG) and weighted gene co-expression network analyses (WGCNA) were done to identify common genes. Enrichment analysis and protein-protein interaction network were used to explore potential molecular pathways and crosstalk genes between IgAN and SS. The results were further verified by external validation and immunohistochemistry (IHC) analysis. Additionally, immune cell analysis and transcription factor prediction were also conducted. The DEG analysis revealed 28 commonly up-regulated genes, while WGCNA identified 98 interactively positive-correlated module genes between IgAN and SS. The enrichment analysis suggested that these genes were mainly involved in the biological processes of response to virus and antigen processing and presentation. The external validation and IHC analysis identified 5 hub genes (PSMB8, PSMB9, IFI44, ISG15, and CD53). In the immune cell analysis, the effector memory CD8 T and T follicular helper cells were significantly activated, and the corresponding proportions showed positively correlations with the expressions of the 5 hub genes in the two autoimmune diseases. Together, our data identified the crosstalk genes, molecular pathways, and immune cells underlying the IgAN and SS, which provides valuable insights into the intricate mechanisms of these diseases and offers potential intervention targets. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 82170722 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: Autoimmune disease; Bioinformatic analysis; IgA nephropathy; Immunohistochemistry; Sjögren’s syndrome |
| تواريخ الأحداث: | Date Created: 20240813 Date Completed: 20240813 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| مُعرف محوري في PubMed: | PMC11322200 |
| DOI: | 10.1007/s10238-024-01420-1 |
| PMID: | 39136821 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1591-9528 |
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| DOI: | 10.1007/s10238-024-01420-1 |