دورية أكاديمية
أعرض في EDS

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol treatment inhibits abnormal tumor growth by regulating neutrophil infiltration in a non-small cell lung carcinoma mouse model.

التفاصيل البيبلوغرافية
العنوان: 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol treatment inhibits abnormal tumor growth by regulating neutrophil infiltration in a non-small cell lung carcinoma mouse model.
المؤلفون: Kim G; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea; Biotoxtech, 53 Yeongudanji-ro, Ochang-eup, Cheongju-si, South Korea., Kim EY; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea., Lee H; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea., Shin SH; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea., Lee SH; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea., Sohn KY; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea., Kim JW; Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Kwahak-ro, Daejeon, South Korea., Lee JS; Enzychem Lifesciences, 14F aT Center 27 Gangnam-daero, Seoul, South Korea. Electronic address: jaesam.lee@enzychem.com.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117269. Date of Electronic Publication: 2024 Aug 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/immunology , Carcinoma, Lewis Lung*/drug therapy , Carcinoma, Lewis Lung*/pathology , Carcinoma, Lewis Lung*/immunology , Neutrophil Infiltration*/drug effects , Mice, Inbred C57BL* , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/immunology , Tumor Microenvironment*/drug effects, Animals ; Mice ; Diglycerides/pharmacology ; Cell Line, Tumor ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; Disease Models, Animal ; Male ; Antineoplastic Agents/pharmacology ; Glycerides
مستخلص: Excessive neutrophil infiltration into the tumor microenvironment (TME) is an important factor that contributes to tumor overgrowth and limited immunotherapy efficacy. Neutrophils activate various receptors involved in tumor progression, while suppressing the infiltration and activity of cytotoxic T cells and creating optimal conditions for tumor growth. Therefore, the appropriate control of neutrophil infiltration is an effective strategy for tumor treatment. In the present study, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) inhibited tumor overgrowth by suppressing excessive neutrophil infiltration, resulting in >74.97 % reduction in tumor size in a Lewis lung carcinoma (LLC-1) mouse model. All subjects in the positive control group died during the 90-day survival period, whereas only four subjects in the PLAG treatment group survived. PLAG had a significantly higher tumor growth inhibitory effect and survival rate than other neutrophil infiltration-targeting inhibitors (e.g., Navarixin, lymphocyte antigen 6 complex locus G6D antibody [aLy6G]). The ability of PLAG to regulate neutrophil infiltration and inhibit tumor growth depends on thioredoxin-interacting protein (TXNIP). In tumors lacking TXNIP expression, PLAG failed to control neutrophil infiltration and infiltration-related factor release, and the inhibitory effect of PLAG on tumor growth was reduced. PLAG-mediated inhibition of neutrophil infiltration enhances the efficacy of immune checkpoint inhibitors (ICIs), increasing the antitumor efficacy and survival rate by 30 %. In conclusion, PLAG could be a novel alternative to anti-tumor drugs that effectively targets excessive neutrophil infiltration into cancer tissues.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: NSCLC; PLAG; TXNIP; immune checkpoint inhibitor; tumor-infiltrating neutrophils
المشرفين على المادة: 0 (1-palmitoyl-2-linoleoyl-3-acetyl-rac glycerol)
0 (Diglycerides)
0 (Antineoplastic Agents)
0 (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol)
0 (Glycerides)
تواريخ الأحداث: Date Created: 20240813 Date Completed: 20240824 Latest Revision: 20240824
رمز التحديث: 20240826
DOI: 10.1016/j.biopha.2024.117269
PMID: 39137654
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2024.117269