دورية أكاديمية
To target cellular senescence in diabetic kidney disease: the known and the unknown.
| العنوان: | To target cellular senescence in diabetic kidney disease: the known and the unknown. |
|---|---|
| المؤلفون: | Wei Y; Department of Diabetes, School of Translational Medicine, Monash University, Melbourne, Australia.; Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Ren Ji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Mou S; Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Ren Ji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Yang Q; Department of Nephrology, Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China., Liu F; Department of Nephrology, Laboratory of Diabetic Kidney Disease, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China., Cooper ME; Department of Diabetes, School of Translational Medicine, Monash University, Melbourne, Australia., Chai Z; Department of Diabetes, School of Translational Medicine, Monash University, Melbourne, Australia. |
| المصدر: | Clinical science (London, England : 1979) [Clin Sci (Lond)] 2024 Aug 21; Vol. 138 (16), pp. 991-1007. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Portland Press on behalf of the Medical Research Society and the Biochemical Society Original Publication: London, Medical Research Society. |
| مواضيع طبية MeSH: | Cellular Senescence* , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology, Humans ; Animals ; Autophagy ; Kidney/pathology ; Kidney/metabolism ; Senescence-Associated Secretory Phenotype ; Endoplasmic Reticulum Stress |
| مستخلص: | Cellular senescence represents a condition of irreversible cell cycle arrest, characterized by heightened senescence-associated beta-galactosidase (SA-β-Gal) activity, senescence-associated secretory phenotype (SASP), and activation of the DNA damage response (DDR). Diabetic kidney disease (DKD) is a significant contributor to end-stage renal disease (ESRD) globally, with ongoing unmet needs in terms of current treatments. The role of senescence in the pathogenesis of DKD has attracted substantial attention with evidence of premature senescence in this condition. The process of cellular senescence in DKD appears to be associated with mitochondrial redox pathways, autophagy, and endoplasmic reticulum (ER) stress. Increasing accumulation of senescent cells in the diabetic kidney not only leads to an impaired capacity for repair of renal injury, but also the secretion of pro-inflammatory and profibrotic cytokines and growth factors causing inflammation and fibrosis. Current treatments for diabetes exhibit varying degrees of renoprotection, potentially via mitigation of senescence in the diabetic kidney. Targeting senescent cell clearance through pharmaceutical interventions could emerge as a promising strategy for preventing and treating DKD. In this paper, we review the current understanding of senescence in DKD and summarize the possible therapeutic interventions relevant to senescence in this field. (© 2024 The Author(s).) |
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| معلومات مُعتمدة: | APP2011355 National Health and Medical Research Council (NHMRC) |
| فهرسة مساهمة: | Keywords: Cellular Senescence; diabetic nephropathy; inlfammation; renal fibrosis |
| تواريخ الأحداث: | Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240818 |
| رمز التحديث: | 20240818 |
| مُعرف محوري في PubMed: | PMC11327223 |
| DOI: | 10.1042/CS20240717 |
| PMID: | 39139135 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1470-8736 |
|---|---|
| DOI: | 10.1042/CS20240717 |