دورية أكاديمية
أعرض في EDS

Examining the Effectiveness of Polyamidoamine (PAMAM) Dendrimers for Enamel Lesion Remineralization: A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: Examining the Effectiveness of Polyamidoamine (PAMAM) Dendrimers for Enamel Lesion Remineralization: A Systematic Review.
المؤلفون: Sanka SM; Pediatric and Preventive Dentistry, Sri Ramaswamy Memorial (SRM) Kattankulathur Dental College and Hospital, Chennai, IND., Ramar K; Pedodontics and Preventive Dentistry, Sri Ramaswamy Memorial (SRM) Kattankulathur Dental College and Hospital, Chennai, IND.
المصدر: Cureus [Cureus] 2024 Jul 13; Vol. 16 (7), pp. e64490. Date of Electronic Publication: 2024 Jul 13 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: White spot lesions (WSLs) and demineralized enamel surfaces are common dental issues that can lead to further complications if untreated. The potential of various remineralizing agents has been extensively studied, but the efficacy of polyamidoamine (PAMAM) dendrimers in promoting enamel remineralization remains to be fully elucidated. This systematic review aims to evaluate the remineralizing potential of PAMAM on WSLs and demineralized enamel surfaces. To identify relevant studies, a comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, and Cochrane Library. Inclusion criteria comprised in vitro and in vivo studies that assessed the effects of PAMAM on WSLs or demineralized enamel. Data extraction and quality assessment were performed independently by two reviewers. The primary outcomes measured were changes in enamel microhardness, surface morphology, and mineral content. Five studies met the inclusion criteria, comprising in vitro studies. The results indicated that PAMAM demonstrated a significant remineralizing effect on demineralized enamel surfaces, as evidenced by increased microhardness and improved surface morphology. The studies varied in their methodological approaches but collectively supported the potential of PAMAM in enamel remineralization. PAMAM dendrimers exhibit promising remineralizing properties for treating WSLs and demineralized enamel surfaces.
Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
(Copyright © 2024, Sanka et al.)
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فهرسة مساهمة: Keywords: a systematic review; dendrimers; enamel remineralization; remineralizing agents; surface microhardness
تواريخ الأحداث: Date Created: 20240814 Latest Revision: 20240815
رمز التحديث: 20240815
مُعرف محوري في PubMed: PMC11320914
DOI: 10.7759/cureus.64490
PMID: 39139334
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.64490