دورية أكاديمية
أعرض في EDS

Prognosis in Patients with ST-Segment Elevation Myocardial Infarction Reperfused by PHDP: 1-Year MACEs Follow-Up.

التفاصيل البيبلوغرافية
العنوان: Prognosis in Patients with ST-Segment Elevation Myocardial Infarction Reperfused by PHDP: 1-Year MACEs Follow-Up.
المؤلفون: Dou J; School of Medicine, Chengde Medical University, Chengde 067000, Hebei, China., Gao J; School of Medicine, Chengde Medical University, Chengde 067000, Hebei, China., Yang HH; School of Medicine, Chengde Medical University, Chengde 067000, Hebei, China., Guo R; School of Medicine, Chengde Medical University, Chengde 067000, Hebei, China., Jiang C; School of Medicine, Chengde Medical University, Chengde 067000, Hebei, China., Zhou J; Department of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde 067000, Hebei, China., Yu X; Department of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde 067000, Hebei, China., Guo J; Department of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde 067000, Hebei, China., Zhang J; Department of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde 067000, Hebei, China., Luo D; Department of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde 067000, Hebei, China.
المصدر: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2024 Jan-Dec; Vol. 30, pp. 10760296241271394.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9508125 Publication Model: Print Cited Medium: Internet ISSN: 1938-2723 (Electronic) Linking ISSN: 10760296 NLM ISO Abbreviation: Clin Appl Thromb Hemost Subsets: MEDLINE
أسماء مطبوعة: Publication: Thousand Oaks, CA : Sage Publications
Original Publication: New York, N.Y. : Raven Press, c1995-
مواضيع طبية MeSH: ST Elevation Myocardial Infarction*/surgery, Humans ; Male ; Female ; Middle Aged ; Follow-Up Studies ; Aged ; Prognosis ; Percutaneous Coronary Intervention/methods ; Recombinant Proteins/therapeutic use
مستخلص: This study explored 1-year follow-up of Parmaco-invasive strategy with half-dose recombinant human prourokinase (PHDP) in patients with acute ST-segment elevation myocardial infarction (STEMI). The follow-up endpoints were major adverse cardiovascular events (MACEs) occurring within 30 days and 1 year, as well as postoperative bleeding events. The study ultimately included 150 subjects, with 75 in the primary percutaneous coronary intervention (PPCI) group and 75 in the PHDP group. This study found that the PHDP group had a shorter FMC-reperfusion time (42.00 min vs 96.00 min, P < 0.001). During PCI, the PHDP group had a lower percutaneous transluminal coronary angioplasty (PTCA) ( P  = 0.021), intropin ( P  = 0.002) and tirofiban ( P  < 0.001) use. And the incidence of intraoperative arrhythmia, malignant arrhythmia, and slow flow/no-reflow was lower in the PHDP group ( P  < 0.001). At the 30-day follow-up, there was a significantly higher proportion of patients in the PPCI group who were readmitted due to unstable angina ( P  = 0.037). After 1 year of follow-up, there was no statistically significant difference in MACEs between the two groups ( P  = 0.500). The incidence of postoperative major bleeding, intracranial bleeding, and minor bleeding did not differ between the PHDP and PPCI groups ( P  > 0.05). The PHDP facilitates early treatment of infarct-related vessels, shortens FMC-reperfusion time, and does not increase the risk of MACEs.
Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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فهرسة مساهمة: Keywords: ST-segment elevation myocardial infarction; fibrinolysis; major adverse cardiovascular events‌; percutaneous coronary intervention; recombinant human prourokinase
المشرفين على المادة: 0 (Recombinant Proteins)
تواريخ الأحداث: Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240817
رمز التحديث: 20240817
مُعرف محوري في PubMed: PMC11325463
DOI: 10.1177/10760296241271394
PMID: 39140859
قاعدة البيانات: MEDLINE
الوصف
تدمد:1938-2723
DOI:10.1177/10760296241271394