دورية أكاديمية
Multi-type maternal diabetes mellitus affects human placental villous geometric morphology: A three-dimensional imaging study.
| العنوان: | Multi-type maternal diabetes mellitus affects human placental villous geometric morphology: A three-dimensional imaging study. |
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| المؤلفون: | Gao X; Department of Obstetrics and Gynaecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China., Qin X; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China., Pei S; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China., Wang W; Department of Obstetrics and Gynaecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China., Wu R; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China., Mei J; Department of Obstetrics and Gynaecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China., Liu Y; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China., Xie Y; Department of Obstetrics and Gynaecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address: xieyao@med.uestc.edu.cn., Ni G; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address: guangmingni@uestc.edu.cn. |
| المصدر: | Placenta [Placenta] 2024 Sep 26; Vol. 155, pp. 70-77. Date of Electronic Publication: 2024 Jul 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3102 (Electronic) Linking ISSN: 01434004 NLM ISO Abbreviation: Placenta Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010- > : Amsterdam : Elsevier Original Publication: London W.B. Saunders. |
| مواضيع طبية MeSH: | Imaging, Three-Dimensional* , Diabetes, Gestational*/pathology , Diabetes, Gestational*/diagnostic imaging , Chorionic Villi*/pathology , Chorionic Villi*/diagnostic imaging , Diabetes Mellitus, Type 2*/pathology , Diabetes Mellitus, Type 2*/diagnostic imaging , Diabetes Mellitus, Type 1*/pathology , Diabetes Mellitus, Type 1*/diagnostic imaging , Pregnancy in Diabetics*/pathology , Pregnancy in Diabetics*/diagnostic imaging , Tomography, Optical Coherence*/methods, Humans ; Female ; Pregnancy ; Adult ; Placenta/diagnostic imaging ; Placenta/pathology |
| مستخلص: | Introduction: Diabetes mellitus leads to maldevelopment of the villous morphology in the human placenta, disrupting the exchange of materials between the maternal and fetal compartments, consequently compromising fetal development. This study aims to explore how different types of diabetes mellitus affect human placental villous geometric morphology including branching numbers and sizes (length, diameter). Methods: Here an optical coherence tomography (OCT)-based 3D imaging platform was utilized to capture 3D images of placental villi from different types of diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM). Results: Different types of diabetes mellitus exhibit different effects on human placental villous geometric morphological parameters: GDM had greater placenta villous parameters at intermediate villous diameter (IVD), terminal villous diameter (TVD), terminal villous length (TVL) compared to the healthy, T1DM, and T2DM, and these differences were statistically significant. The TVD of T1DM and T2DM had significantly greater sizes than the healthy. There was no statistically significant difference in the number of villous branches among the three types of diabetes, but T1DM and GDM had more villous branches than healthy individuals. Discussion: Diabetes mellitus affects the geometric morphology of human placental villi, with varying effects observed in pregnancies of different diabetes types. These findings offer a novel avenue for exploring underlying pathophysiological mechanisms and enhancing the management of women with diabetes from preconception through pregnancy. Competing Interests: Declaration of competing interest The author(s) declare that they have no conflict of interest. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 3D imaging; Diabetes mellitus; Human placental villus; Optical coherence tomography |
| تواريخ الأحداث: | Date Created: 20240814 Date Completed: 20240915 Latest Revision: 20240918 |
| رمز التحديث: | 20240918 |
| DOI: | 10.1016/j.placenta.2024.07.310 |
| PMID: | 39141963 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-3102 |
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| DOI: | 10.1016/j.placenta.2024.07.310 |