دورية أكاديمية
أعرض في EDS

Blood metabolites mediate effects of breakfast skipping on heart failure via Mendelian randomization analysis.

التفاصيل البيبلوغرافية
العنوان: Blood metabolites mediate effects of breakfast skipping on heart failure via Mendelian randomization analysis.
المؤلفون: Lv L; Department of Cardiology, The Second Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China., Guo Y; Department of Cardiology, The Frist Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China., Zheng Z; Department of Urology, The First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China., Li B; Department of Cardiology, The Second Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China. libao_medical@163.com.
المصدر: Scientific reports [Sci Rep] 2024 Aug 15; Vol. 14 (1), pp. 18957. Date of Electronic Publication: 2024 Aug 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Breakfast* , Genome-Wide Association Study* , Heart Failure*/blood , Heart Failure*/genetics , Intermittent Fasting*/adverse effects , Intermittent Fasting*/blood , Mendelian Randomization Analysis*, Humans ; Risk Factors
مستخلص: Numerous observational studies have suggested a potential causal relationship between skipping breakfast and cardiovascular diseases, including heart failure (HF). However, these studies are susceptible to inherent confounders and the challenge of reverse causation, and the underlying metabolic factors are not yet clear. Therefore, our aim is to assess the causal impact of breakfast skipping on HF and the role of potential mediating metabolic products from a genetic perspective, by conducting Mendelian Randomization (MR) studies and mediation analysis. We leveraged summary data from the most extensive genome-wide association studies to date on breakfast skipping (with 193,860 participants), blood metabolites (with 118,461 participants), and HF (involving 47,309 cases and 930,014 controls). To explore the causal relationship between breakfast skipping and HF, as well as the role of 249 potential blood metabolite mediators, we conducted bidirectional MR and mediation MR analyses. We primarily employed the Inverse Variance Weighted (IVW) method, complemented by various other techniques to ensure the comprehensiveness and reliability of our analysis. Our research confirms a causal association between breakfast skipping and an increased risk of HF (odds ratio [OR]: 1.378, 95% confidence interval [CI]: 1.047-1.813; p = 0.022). Furthermore, our research findings demonstrate that breakfast skipping is positively correlated with 6 blood metabolites and negatively correlated with 2 others. Notably, our mediation MR analysis further reveals that three blood metabolites act as mediators in the relationship between breakfast skipping and the risk of HF. Specifically, the mediating effects are attributed to the ratio of docosahexaenoic acid (DHA) to total fatty acids (proportion mediated = 9.41%, 95% CI: 2.10-28.61%), glucose (proportion mediated = 6.17%, 95% CI: 0.97-28.53%), and glycoprotein acetyls (GlycA) (proportion mediated = 5.68%, 95% CI: 0.94-21.62%). The combined mediating effects of these three factors total 20.53% (95%CI: 8.59-91.06%). Our research confirms the causal relationship between genetically instrumented breakfast skipping and HF, underscoring the potential mediating roles played by three key blood metabolites: ratio of DHA to total fatty acids, glucose and GlycA. This discovery offers valuable perspectives for clinical strategies targeting HF.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 2021RC01 Shanxi Province medical science and technology innovation talent strong medical plan; 2021XM09 Key Medical Research Projects of Shanxi Province
تواريخ الأحداث: Date Created: 20240815 Date Completed: 20240815 Latest Revision: 20240819
رمز التحديث: 20240820
مُعرف محوري في PubMed: PMC11327247
DOI: 10.1038/s41598-024-69874-7
PMID: 39147796
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-69874-7