دورية أكاديمية
Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations.
| العنوان: | Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations. |
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| المؤلفون: | Caverzan MD; Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados (IITEMA), Universidad Nacional de Rio Cuarto (UNRC) y Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Río Cuarto X5800BIA, Argentina; Departamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Rio Cuarto, Rio Cuarto X5800BIA, Argentina., Ibarra LE; Departamento de Biología Molecular, Facultad de Ciencias Exactas, Fisicoquímicas y Naturales, Universidad Nacional de Rio Cuarto, Rio Cuarto X5800BIA, Argentina; Instituto de Biotecnología Ambiental y Salud (INBIAS), Universidad Nacional de Rio Cuarto (UNRC) y Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rio Cuarto X5800BIA, Argentina. Electronic address: libarra@exa.unrc.edu.ar. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 2), pp. 134777. Date of Electronic Publication: 2024 Aug 15. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Receptors, Transferrin*/metabolism , Iron*/metabolism , Ferroptosis*/drug effects , Glioblastoma*/metabolism , Glioblastoma*/drug therapy , Glioblastoma*/pathology, Humans ; Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Antigens, CD/metabolism ; Antigens, CD/genetics ; Iron Chelating Agents/therapeutic use ; Iron Chelating Agents/pharmacology |
| مستخلص: | Glioblastoma (GBM) represents a formidable challenge in oncology, characterized by aggressive proliferation and poor prognosis. Iron metabolism plays a critical player in GBM progression, with dysregulated iron uptake and utilization contributing to tumor growth and therapeutic resistance. Iron's pivotal role in DNA synthesis, oxidative stress, and angiogenesis underscores its significance in GBM pathogenesis. Elevated expression of iron transporters, such as transferrin receptor 1 (TfR1), highlights the tumor's reliance on iron for survival. Innovative treatment strategies targeting iron dysregulation hold promise for overcoming therapeutic challenges in GBM management. Approaches such as iron chelation therapies, induction of ferroptosis to nanoparticle-based drug delivery systems exploit iron-dependent vulnerabilities, offering avenues for enhance treatment efficacy and improve patient outcomes. As research advances, understanding the complexities of iron-mediated carcinogenesis provides a foundation for developing precision medicine approaches tailored to combat GBM effectively. This review explores the intricate relationship between iron metabolism and GBM, elucidating its multifaceted implications and therapeutic opportunities. By consolidating the latest insights into iron metabolism in GBM, this review underscores its potential as a therapeutic target for improving patient care in combination with the standard of care approach. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Ferroptosis; Glioblastoma; Iron; Nanoparticles; Target therapy; Transferrin receptor |
| المشرفين على المادة: | 0 (Receptors, Transferrin) E1UOL152H7 (Iron) 0 (CD71 antigen) 0 (Antigens, CD) 0 (Iron Chelating Agents) |
| تواريخ الأحداث: | Date Created: 20240817 Date Completed: 20240917 Latest Revision: 20240917 |
| رمز التحديث: | 20240917 |
| DOI: | 10.1016/j.ijbiomac.2024.134777 |
| PMID: | 39153669 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2024.134777 |