دورية أكاديمية
Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis.
| العنوان: | Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis. |
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| المؤلفون: | Roffler AA; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States., Maurer DP; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States., Lunn TJ; Department of Biological Sciences, University of Arkansas, Fayetteville, AR, United States., Sironen T; Department of Virology, University of Helsinki, Helsinki, Finland.; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland., Forbes KM; Department of Biological Sciences, University of Arkansas, Fayetteville, AR, United States., Schmidt AG; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.; Department of Microbiology, Harvard Medical School, Boston, MA, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Aug 02; Vol. 15, pp. 1269760. Date of Electronic Publication: 2024 Aug 02 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Chiroptera*/virology , Chiroptera*/immunology , Immunity, Humoral* , Antibodies, Viral*/immunology , Zoonoses*/immunology , Zoonoses*/transmission , Zoonoses*/virology, Animals ; Humans ; Adaptive Immunity/immunology |
| مستخلص: | Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV). Bats often tolerate these viruses without noticeable adverse immunological effects or succumbing to disease. Previous studies have largely focused on the role of the bat's innate immune response to control viral pathogenesis, but little is known about bat adaptive immunity. A key component of adaptive immunity is the humoral response, comprised of antibodies that can specifically recognize viral antigens with high affinity. The antibody genes within the 1,400 known bat species are highly diverse, and these genetic differences help shape fundamental aspects of the antibody repertoire, including starting diversity and viral antigen recognition. Whether antibodies in bats protect, mediate viral clearance, and prevent transmission within bat populations is poorly defined. Furthermore, it is unclear how neutralizing activity and Fc-mediated effector functions contribute to bat immunity. Although bats have canonical Fc genes (e.g., mu, gamma, alpha, and epsilon), the copy number and sequences of their Fc genes differ from those of humans and mice. The function of bat antibodies targeting viral antigens has been speculated based on sequencing data and polyclonal sera, but functional and biochemical data of monoclonal antibodies are lacking. In this review, we summarize current knowledge of bat humoral immunity, including variation between species, their potential protective role(s) against viral transmission and replication, and address how these antibodies may contribute to population dynamics within bats communities. A deeper understanding of bat adaptive immunity will provide insight into immune control of transmission and replication for emerging viruses with the potential for zoonotic spillover. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Roffler, Maurer, Lunn, Sironen, Forbes and Schmidt.) |
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| معلومات مُعتمدة: | P01 AI089618 United States AI NIAID NIH HHS; R01 AI146779 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Chiroptera; bat immunity; humoral responses; immunoglobulin repertoire; infectious diseases |
| المشرفين على المادة: | 0 (Antibodies, Viral) |
| تواريخ الأحداث: | Date Created: 20240819 Date Completed: 20240819 Latest Revision: 20240923 |
| رمز التحديث: | 20240923 |
| مُعرف محوري في PubMed: | PMC11329927 |
| DOI: | 10.3389/fimmu.2024.1269760 |
| PMID: | 39156901 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2024.1269760 |