دورية أكاديمية
أعرض في EDS

Comparison of subjective cognitive decline and polygenic risk score in the prediction of all-cause dementia, Alzheimer's disease and vascular dementia.

التفاصيل البيبلوغرافية
العنوان: Comparison of subjective cognitive decline and polygenic risk score in the prediction of all-cause dementia, Alzheimer's disease and vascular dementia.
المؤلفون: Trares K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. k.trares@dkfz-heidelberg.de., Stocker H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany., Stevenson-Hoare J; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany., Perna L; Department Genes and Environment, Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, 80804, Munich, Germany., Holleczek B; Saarland Cancer Registry, Neugeländstraße 9, 66117, Saarbrücken, Germany., Beyreuther K; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany., Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany.
المصدر: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Aug 19; Vol. 16 (1), pp. 188. Date of Electronic Publication: 2024 Aug 19.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central Ltd.
مواضيع طبية MeSH: Alzheimer Disease*/genetics , Dementia, Vascular*/genetics , Cognitive Dysfunction*/genetics , Cognitive Dysfunction*/diagnosis , Multifactorial Inheritance*/genetics, Humans ; Female ; Male ; Aged ; Middle Aged ; Cohort Studies ; Dementia/genetics ; Dementia/epidemiology ; Dementia/diagnosis ; Risk Factors ; Genetic Risk Score
مستخلص: Background: Polygenic risk scores (PRS) and subjective cognitive decline (SCD) are associated with the risk of developing dementia. It remains to examine whether they can improve the established cardiovascular risk factors aging and dementia (CAIDE) model and how their predictive abilities compare.
Methods: The CAIDE model was applied to a sub-sample of a large, population-based cohort study (n = 5,360; aged 50-75) and evaluated for the outcomes of all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VD) by calculating Akaike's information criterion (AIC) and the area under the curve (AUC). The improvement of the CAIDE model by PRS and SCD was further examined using the net reclassification improvement (NRI) method and integrated discrimination improvement (IDI).
Results: During 17 years of follow-up, 410 participants were diagnosed with dementia, including 139 AD and 152 VD diagnoses. Overall, the CAIDE model showed high discriminative ability for all outcomes, reaching AUCs of 0.785, 0.793, and 0.789 for all-cause dementia, AD, and VD, respectively. Adding information on SCD significantly increased NRI for all-cause dementia (4.4%, p = 0.04) and VD (7.7%, p = 0.01). In contrast, prediction models for AD further improved when PRS was added to the model (NRI, 8.4%, p = 0.03). When APOE ε4 carrier status was included (CAIDE Model 2), AUCs increased, but PRS and SCD did not further improve the prediction.
Conclusions: Unlike PRS, information on SCD can be assessed more efficiently, and thus, the model including SCD can be more easily transferred to the clinical setting. Nevertheless, the two variables seem negligible if APOE ε4 carrier status is available.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Alzheimer’s disease; CAIDE; Cohort study; Dementia; Polygenic risk score; Risk prediction; Subjective cognitive decline; Vascular dementia
تواريخ الأحداث: Date Created: 20240819 Date Completed: 20240819 Latest Revision: 20240822
رمز التحديث: 20240822
مُعرف محوري في PubMed: PMC11331600
DOI: 10.1186/s13195-024-01559-9
PMID: 39160600
قاعدة البيانات: MEDLINE
الوصف
تدمد:1758-9193
DOI:10.1186/s13195-024-01559-9