دورية أكاديمية
The autoimmune nature of morphine addiction.
| العنوان: | The autoimmune nature of morphine addiction. |
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| المؤلفون: | Sirenko VV; Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Avenue, St. Petersburg, 194064, Russia. Electronic address: sirw@mail.ru. |
| المصدر: | Journal of psychiatric research [J Psychiatr Res] 2024 Oct; Vol. 178, pp. 225-227. Date of Electronic Publication: 2024 Aug 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon Press |
| مواضيع طبية MeSH: | Morphine Dependence*/immunology, Humans ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Morphine/administration & dosage ; Receptors, Opioid/immunology ; Receptors, Opioid/metabolism |
| مستخلص: | The onset of the disease as a morphine addiction is associated with the appearance in the patient's body of antibodies directed against opiate receptors (ORs). Once anti-opiate receptor antibodies (anti-OR antibodies) appear in the blood they will tend to bind to ORs. Such binding will cause blocking of physiological functions of OR. The blockage is felt by a morphine addict as withdrawal syndrome. To get rid of this harmful condition, the addict increases the dose of morphine taken. This is where tolerance manifests itself. The drug addict is forced to increase the dose of morphine from time to time because of the body responds by producing the more and more anti-OR antibodies. The immunological nature of morphine addiction is the reason for lifelong changes in the body's reactivity to the drug. An addict can be cured if he gets rid of B- and T-memory cells, which specifically react to ORs. Competing Interests: Declaration of competing interest None. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autoantibodies; Drug addiction; Immune system; Opiate dependence; Tolerance; Withdrawal syndrome |
| المشرفين على المادة: | 0 (Autoantibodies) 76I7G6D29C (Morphine) 0 (Receptors, Opioid) |
| تواريخ الأحداث: | Date Created: 20240820 Date Completed: 20240909 Latest Revision: 20240923 |
| رمز التحديث: | 20240924 |
| DOI: | 10.1016/j.jpsychires.2024.08.028 |
| PMID: | 39163660 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-1379 |
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| DOI: | 10.1016/j.jpsychires.2024.08.028 |