دورية أكاديمية
Different imaging techniques' diagnostic efficacy for Crohn's disease activity and external validation and comparison of MDCTAs, SES-CD and IBUSSAS.
| العنوان: | Different imaging techniques' diagnostic efficacy for Crohn's disease activity and external validation and comparison of MDCTAs, SES-CD and IBUSSAS. |
|---|---|
| المؤلفون: | Long X; Department of Ultrasonography, Nanjing Drum Tower Hospital, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 21009, China., Peng C; Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing, 21009, China., Zhang X; Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing, 21009, China., Kong W; Department of Ultrasonography, Nanjing Drum Tower Hospital, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 21009, China. breezewen@163.com., Gong L; Department of Ultrasonography, Nanjing Drum Tower Hospital, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 21009, China. gongli2010@163.com. |
| المصدر: | BMC gastroenterology [BMC Gastroenterol] 2024 Aug 20; Vol. 24 (1), pp. 277. Date of Electronic Publication: 2024 Aug 20. |
| نوع المنشور: | Journal Article; Comparative Study; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Crohn Disease*/diagnostic imaging , Severity of Illness Index* , Multidetector Computed Tomography*/methods, Humans ; Male ; Female ; Adult ; Middle Aged ; Sensitivity and Specificity ; Ultrasonography/methods ; Young Adult ; Ultrasonography, Doppler, Color |
| مستخلص: | Background: Crohn's disease (CD) is a chronic inflammatory disease of the digestive tract with unknown etiology. It follows a relapse-remission pattern, making disease activity assessment crucial for treatment. Our study aims to evaluate the diagnostic accuracy of various imaging modalities and to validate and compare the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS), the multidetector computed tomography enterography score (MDCTEs), and the simplified endoscopic activity score for Crohn's disease (SES-CD). Methods: We assessed diagnostic performance using the CD Activity Index (CDAI). We first categorized patients into remission and active groups. For those in the active stage, we further categorized them into mild/moderate and severe activity groups. We used Spearman rank correlation to evaluate the relationships among IBUS-SAS, bowel wall thickness (BWT), Color Doppler imaging signal (CDS), inflammatory fat (i-fat), bowel wall stratification (BWS), and clinical inflammatory indicators. Results: A total of 103 CD patients were evaluated. The IBUS-SAS cut-off for remission and activity was 23.8, with an AUC of 0.923, sensitivity of 91.4%, and specificity of 84.8%. The SES-CD had an AUC of 0.801, sensitivity of 62.9%, and specificity of 84.4% at a cut-off of 4.5. The MDCTEs showed an AUC of 0.855, sensitivity of 77.1%, and specificity of 75.8% for a cut-off of 6.5. The Delong test revealed significant differences in diagnostic efficacy when comparing IBUS-SAS to SES-CD and IBUS-SAS to MDCTEs. In the group of mild or moderate-to-severe active, the IBUS-SAS had an AUC of 0.925, sensitivity of 83.7%, and specificity of 88.9% at a cut-off of 40. The SES-CD exhibited an AUC of 0.850, sensitivity of 90.7%, and specificity of 70.4% at a cut-off of 8.5. MDCTEs showed an AUC of 0.909, sensitivity of 83.7%, and specificity of 85.2% at a cut-off of 8.5. During Delong test, the IBUS-SAS, MDCTEs, and SES-CD showed no significant differences in assessing moderate-to-severe activity. Both IBUS-SAS and ultrasound parameters correlated with certain serum indicators (p < 0.05), although only weakly to moderately (all r < 0.5). Conclusion: The IBUS-SAS, MDCTEs and SES-CD can evaluate disease remission/active and mild/moderate-to-severe active in CD, and IBUS-SAS offers the potential to precisely define CD activity. (© 2024. The Author(s).) |
| References: | Br J Radiol. 2020 May 01;93(1109):20190614. (PMID: 32101466) J Crohns Colitis. 2019 Feb 1;13(2):144-164. (PMID: 30137275) J Crohns Colitis. 2021 Apr 6;15(4):609-616. (PMID: 33098642) Pediatr Radiol. 2017 Sep;47(10):1321-1328. (PMID: 28470387) Inflamm Bowel Dis. 2021 May 17;27(6):e67-e68. (PMID: 33512456) JAMA. 2021 Jan 05;325(1):69-80. (PMID: 33399844) J Pediatr Gastroenterol Nutr. 2019 Oct;69(4):461-465. (PMID: 31136561) J Ultrasound Med. 2021 Dec;40(12):2595-2605. (PMID: 33595133) Inflamm Bowel Dis. 2009 Dec;15(12):1859-66. (PMID: 19575357) Surg Clin North Am. 2019 Dec;99(6):1063-1082. (PMID: 31676048) Abdom Radiol (NY). 2023 Mar;48(3):821-832. (PMID: 36525049) Gastrointest Endosc. 2004 Oct;60(4):505-12. (PMID: 15472670) Scand J Gastroenterol. 2023 Jul-Dec;58(8):883-889. (PMID: 36825305) J Med Life. 2021 May-Jun;14(3):310-315. (PMID: 34377195) Aliment Pharmacol Ther. 2011 Jul;34(2):125-45. (PMID: 21615440) Lancet. 2018 Dec 23;390(10114):2779-2789. (PMID: 29096949) World J Gastroenterol. 2008 Jul 14;14(26):4127-30. (PMID: 18636655) Gut. 2018 May;67(5):973-985. (PMID: 29437914) J Crohns Colitis. 2023 Oct 20;17(9):1387-1394. (PMID: 37023010) Cochrane Database Syst Rev. 2016 Aug 08;(8):CD010642. (PMID: 27501379) Curr Drug Targets. 2014;15(11):1056-63. (PMID: 25198784) Gut. 2019 Dec;68(Suppl 3):s1-s106. (PMID: 31562236) J Crohns Colitis. 2022 May 10;16(4):554-580. (PMID: 34614172) Inflamm Bowel Dis. 2015 Mar;21(3):623-30. (PMID: 25647154) Dig Dis Sci. 2022 Jun;67(6):2492-2502. (PMID: 34052948) Medicine (Baltimore). 2021 Feb 12;100(6):e24717. (PMID: 33578614) J Crohns Colitis. 2019 Mar 26;13(3):273-284. (PMID: 30137278) Inflamm Bowel Dis. 2011 May;17(5):1073-80. (PMID: 21484958) Gastroenterology. 2018 Mar;154(4):1172-1194. (PMID: 29329905) Med Res Rev. 2022 Sep;42(5):1856-1887. (PMID: 35603998) Lancet Gastroenterol Hepatol. 2020 Jan;5(1):17-30. (PMID: 31648971) |
| فهرسة مساهمة: | Keywords: Computed tomography; Crohn’s Disease; Diagnostic imaging; Endoscopy; Ultrasonography |
| تواريخ الأحداث: | Date Created: 20240820 Date Completed: 20240821 Latest Revision: 20240823 |
| رمز التحديث: | 20240823 |
| مُعرف محوري في PubMed: | PMC11337638 |
| DOI: | 10.1186/s12876-024-03376-8 |
| PMID: | 39164662 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-230X |
|---|---|
| DOI: | 10.1186/s12876-024-03376-8 |