دورية أكاديمية
Effect of antigen removal in hypersensitivity pneumonitis.
| العنوان: | Effect of antigen removal in hypersensitivity pneumonitis. |
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| المؤلفون: | Robertshaw MJ; Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA., Gorman A; Department of Statistics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Glazer CS; Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA., Adams TN; Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA. traci.adams@utsouthwestern.edu. |
| المصدر: | BMC pulmonary medicine [BMC Pulm Med] 2024 Aug 20; Vol. 24 (1), pp. 398. Date of Electronic Publication: 2024 Aug 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001]- |
| مواضيع طبية MeSH: | Alveolitis, Extrinsic Allergic*/diagnosis , Alveolitis, Extrinsic Allergic*/immunology , Alveolitis, Extrinsic Allergic*/therapy, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Antigens/immunology ; Adult ; Respiratory Function Tests ; Lung Transplantation ; Tomography, X-Ray Computed |
| مستخلص: | Background: Antigen removal is a cornerstone of treatment of hypersensitivity pneumonitis (HP), but its association with transplant-free survival remains unclear. Further, HP guidelines conflict as to whether antigen removal is a recommended diagnostic test in patients with suspected HP. Objective: The purpose of this study is to (1) evaluate the impact of antigen removal on transplant-free survival and (2) to describe the impact of antigen removal on pulmonary function testing and imaging in a retrospective cohort of patients with HP. Methods: We retrospectively identified HP patients evaluated between 2011 and 2020. Demographic, physiologic, radiographic, and pathologic data were recorded. Results: 212 patients were included in the cohort. Patients who identified and removed antigen had a better transplant-free survival than patients who did not identify antigen and patients who identified but did not remove antigen. Antigen removal was associated with improvement in FVC by 10% predicted in 16.9% of patients with fibrotic HP and 56.7% of patients with nonfibrotic HP. Discussion: Our results suggest that over 50% of nonfibrotic HP patients and 16.9% of fibrotic HP patients improve with exposure removal. In addition, antigen removal, rather than antigen identification, is associated with transplant-free survival in HP. (© 2024. The Author(s).) |
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| المشرفين على المادة: | 0 (Antigens) |
| تواريخ الأحداث: | Date Created: 20240820 Date Completed: 20240821 Latest Revision: 20240823 |
| رمز التحديث: | 20240823 |
| مُعرف محوري في PubMed: | PMC11337626 |
| DOI: | 10.1186/s12890-024-03098-3 |
| PMID: | 39164720 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2466 |
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| DOI: | 10.1186/s12890-024-03098-3 |