دورية أكاديمية
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Comparative analysis of computed tomography severity indices in predicting the severity and clinical outcome in patients with acute pancreatitis.

التفاصيل البيبلوغرافية
العنوان: Comparative analysis of computed tomography severity indices in predicting the severity and clinical outcome in patients with acute pancreatitis.
المؤلفون: Parmar G; Department of Radiodiagnosis, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India., Mangalore, Karnataka, 575001, India., Noronha GP; Department of Radiodiagnosis, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India., Mangalore, Karnataka, 575001, India., Poornima V; Department of Radiodiagnosis, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India., Mangalore, Karnataka, 575001, India.
المصدر: F1000Research [F1000Res] 2024 Jul 18; Vol. 11, pp. 1272. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2022).
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : F1000 Research Ltd
مواضيع طبية MeSH: Tomography, X-Ray Computed*/methods , Severity of Illness Index* , Pancreatitis*/diagnostic imaging, Humans ; Male ; Female ; Middle Aged ; Adult ; Prospective Studies ; Aged ; Prognosis ; Acute Disease
مستخلص: Background: Acute pancreatitis (AP) has unpredictable severity. Its management is based on initial assessment of disease severity. It ranges from mild interstitial to severe necrotic form; the latter is associated with poor prognosis. Contrast-enhanced computed tomography (CT) of the abdomen is the gold standard in early detection of pancreatic necrosis and in assessing the severity of AP. Two CT grading systems exist to assess the severity of AP: CT severity Index (CSI) and modified CSI (MCSI). This study compares the usefulness of these two systems in predicting the severity and clinical outcome in AP in comparison with Ranson's criteria and clinical outcome parameters. Methods: This is a prospective hospital-based screening study of 80 patients aged >12 years with clinical diagnosis of AP who underwent contrast-enhanced CT study of the abdomen. Comparative analysis between MCSI and CSI with Ranson's criteria and clinical outcome parameters was assessed by Chi-Squared test. Results: The accuracy of CSI and MCSI in predicting the requirement of critical care, superadded infection, multiple organ dysfunction syndrome (MODS) and requirement of intervention were 73.0%, 64.5%, 69.8% 60.9% and 77.2%, 76.0%, 74.4% & 56.6% respectively. Area under the curve for MCSI score was significantly higher (AUC: 0.861; 95% CI: 0.736-0.986) than CSI score (AUC:0.815;95% CI:0.749-0.941). MCSI and CSI showed significant correlation with Ranson's criteria; however, MCSI correlation was better (r:0.53; p<0.01) than CSI (r:0.35;p:0.04). Conclusion: CSI and MCSI are better predictors of severity, clinical outcome and mortality compared with Ranson's criteria, with MCSI being more accurate and better predictor than CSI. The accuracy of MCSI is better than CSI for prediction of requirement of critical care, development of superadded infection and development of MODS in AP. However, CSI and MCSI have low accuracy in predicting intervention in AP.
Competing Interests: No competing interests were disclosed.
(Copyright: © 2024 Parmar G et al.)
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فهرسة مساهمة: Keywords: Acute Pancreatitis; CT severity index; Modified CT severity index; Ranson’s criteria; clinical outcome parameters; hospital stay; multisystem organ dysfunction syndrome; sepsis.
تواريخ الأحداث: Date Created: 20240822 Date Completed: 20240822 Latest Revision: 20240823
رمز التحديث: 20240823
مُعرف محوري في PubMed: PMC11336560
DOI: 10.12688/f1000research.125896.2
PMID: 39170860
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-1402
DOI:10.12688/f1000research.125896.2