دورية أكاديمية
Post kala-azar dermal leishmaniasis burden at the village level in selected high visceral leishmaniasis endemic upazilas in Bangladesh.
| العنوان: | Post kala-azar dermal leishmaniasis burden at the village level in selected high visceral leishmaniasis endemic upazilas in Bangladesh. |
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| المؤلفون: | Ghosh D; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh., Sagar SK; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh., Uddin MR; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh., Rashid MU; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA., Maruf S; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh., Nath R; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh., Islam MN; Communicable Disease Control (CDC), Directorate General of Health Services (DGHS), Mohakhali, Dhaka, Bangladesh., Aktaruzzaman MM; Communicable Disease Control (CDC), Directorate General of Health Services (DGHS), Mohakhali, Dhaka, Bangladesh., Sohel ANM; Communicable Disease Control (CDC), Directorate General of Health Services (DGHS), Mohakhali, Dhaka, Bangladesh., Banjara MR; UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland; Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal., Kroeger A; Centre for Medicine and Society/Institute for Infection Prevention, University Medical Centre, Freiburg, Germany., Aseffa A; UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland., Mondal D; Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh. Electronic address: din63d@icddrb.org. |
| المصدر: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Aug 22; Vol. 147, pp. 107213. Date of Electronic Publication: 2024 Aug 22. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| مستخلص: | Objectives: As post kala-azar Dermal Leishmaniasis (PKDL) threatens the success of the Visceral Leishmaniasis (VL) elimination initiative, we aimed to investigate the PKDL burden, including an active search for PKDL in leprosy-negative skin lesion cases. We also investigated their health-seeking behavior and perceived level of stigma. Methods: This was a cross-sectional survey among inhabitants in the VL-endemic villages of the five most VL-endemic upazilas. VL experts trained medical officers in Upazila Health Complexes (UHCs) and leprosy facilities in PKDL management. Frontline workers conducted house-to-house surveys, referring PKDL suspects to designated centers. Data analysis involved Epi Info version 7 and IBM SPSS Statistics 25. Results: Among 472,435 screened individuals, 4022 had past VL (0.85 %). Among the screened population, 82 were PKDL suspects, and 62 PKDL cases were confirmed. The overall PKDL burden was 1.3 (95 % CI: 1.0-1.7) in the 10,000 population in the endemic villages. Male predominance and macular form of PKDL were observed. Thirty-nine PKDL patients perceived stigma of different levels. Only 27 of 62 (44 %) had received PKDL treatment. Medicine's unavailability and side effects were a major reason behind treatment interruption. Active screening among 137 leprosy-negative PKDL suspects yielded 10 (7.3 %) PKDL cases. Conclusion: The existence of PKDL cases in the VL endemic areas is a concern as those are inter-epidemic reservoirs. As per the WHO roadmap, the PKDL burden must be reduced by 70 % and 100 %, respectively, by 2026 and 2030. NKEP can take the current burden of 1.3 per 10,000 people in VL endemic villages as a baseline. Integrating active case detection for PKDL in leprosy hospitals and screening centers is feasible and worth deploying nationwide. Competing Interests: Declaration of competing interest The authors have no conflicts of interest associated with the material presented in this paper. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Bangladesh; Knowledge; Post kala-azar dermal leishmaniasis; Prevalence; Stigma |
| تواريخ الأحداث: | Date Created: 20240823 Latest Revision: 20240913 |
| رمز التحديث: | 20240914 |
| DOI: | 10.1016/j.ijid.2024.107213 |
| PMID: | 39179149 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-3511 |
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| DOI: | 10.1016/j.ijid.2024.107213 |