دورية أكاديمية
Assessment of Left Atrial Fibrosis by Cardiac Magnetic Resonance Imaging in Ischemic Stroke Patients Without Atrial Fibrillation: A Systematic Review and Meta-Analysis.
| العنوان: | Assessment of Left Atrial Fibrosis by Cardiac Magnetic Resonance Imaging in Ischemic Stroke Patients Without Atrial Fibrillation: A Systematic Review and Meta-Analysis. |
|---|---|
| المؤلفون: | Koh JH; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore., Lim LKE; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore., Tan YK; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore., Goh C; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore., Teo YH; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore., Ho JSY; Department of Medicine National University Health System Singapore City Singapore., Dalakoti M; Department of Cardiology National University Heart Centre Singapore City Singapore., Chan MYY; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore.; Department of Cardiology National University Heart Centre Singapore City Singapore., Sia CH; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore.; Department of Cardiology National University Heart Centre Singapore City Singapore., Yeo LLL; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore.; Division of Neurology, Department of Medicine National University Hospital Singapore City Singapore., Tan BYQ; Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore.; Division of Neurology, Department of Medicine National University Hospital Singapore City Singapore. |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 Sep 03; Vol. 13 (17), pp. e033059. Date of Electronic Publication: 2024 Aug 27. |
| نوع المنشور: | Journal Article; Systematic Review; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Cardiomyopathies*/diagnostic imaging , Cardiomyopathies*/etiology , Cardiomyopathies*/pathology , Cardiomyopathies*/physiopathology , Heart Atria*/diagnostic imaging , Heart Atria*/pathology , Heart Atria*/physiopathology , Ischemic Stroke*/complications , Ischemic Stroke*/diagnostic imaging , Ischemic Stroke*/pathology , Ischemic Stroke*/physiopathology, Humans ; Atrial Function, Left ; Fibrosis ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine/methods |
| مستخلص: | Background: Left atrial (LA) fibrosis is a marker of atrial cardiomyopathy and has been reported to be associated with both atrial fibrillation and ischemic stroke. Elucidating this relationship is clinically important as LA fibrosis could serve as a surrogate biomarker of LA cardiomyopathy. The objective of this study is to investigate the association of LA fibrosis and embolic stroke of undetermined source (ESUS) using cardiac magnetic resonance imaging. Methods and Results: Following an International Prospective Register of Systematic Reviews-registered protocol, 3 blinded reviewers performed a systematic review for studies that quantified the degree of LA fibrosis in patients with ESUS as compared with healthy patients from inception to February 2024. A meta-analysis was conducted in the mean difference. From 7 studies (705 patients), there was a significantly higher degree of LA fibrosis in patients with ESUS compared with healthy controls (MD, 5.71% [95% CI, 3.55%-7.87%], P <0.01). The degree of LA fibrosis was significantly higher in patients with atrial fibrillation than healthy controls (MD, 8.22% [95% CI, 5.62%-10.83%], P <0.01). A similar degree of LA fibrosis was observed in patients with ESUS compared with patients with atrial fibrillation (MD, -0.92% [95% CI, -2.29% to 0.44%], P =0.35). Conclusions: A significantly higher degree of LA fibrosis was found in patients with ESUS as compared with healthy controls. This suggests that LA fibrosis may play a significant role in the pathogenesis of ESUS. Further research is warranted to investigate LA fibrosis as a surrogate biomarker of atrial cardiomyopathy and recurrent stroke risk in patients with ESUS. |
| فهرسة مساهمة: | Keywords: acute stroke; embolic stroke; ischemic stroke; magnetic resonance imaging; modifiable risk factors for stroke |
| تواريخ الأحداث: | Date Created: 20240827 Date Completed: 20240903 Latest Revision: 20240919 |
| رمز التحديث: | 20240919 |
| DOI: | 10.1161/JAHA.123.033059 |
| PMID: | 39190571 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-9980 |
|---|---|
| DOI: | 10.1161/JAHA.123.033059 |