دورية أكاديمية
أعرض في EDS

Ten-Year Outcomes of Radiofrequency Ablation for Locally Recurrent Papillary Thyroid Cancer.

التفاصيل البيبلوغرافية
العنوان: Ten-Year Outcomes of Radiofrequency Ablation for Locally Recurrent Papillary Thyroid Cancer.
المؤلفون: Chung SR; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Baek JH; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. radbaek@naver.com., Choi YJ; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Lee JH; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
المصدر: Korean journal of radiology [Korean J Radiol] 2024 Sep; Vol. 25 (9), pp. 851-858.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Korean Society of Radiology Country of Publication: Korea (South) NLM ID: 100956096 Publication Model: Print Cited Medium: Internet ISSN: 2005-8330 (Electronic) Linking ISSN: 12296929 NLM ISO Abbreviation: Korean J Radiol Subsets: MEDLINE
أسماء مطبوعة: Publication: October 2008-: Seoul, Korea : Korean Society of Radiology
Original Publication: Seoul, Korea : Korean Radiological Society, 2000-August 2008.
مواضيع طبية MeSH: Thyroid Neoplasms*/surgery , Thyroid Neoplasms*/pathology , Neoplasm Recurrence, Local*/surgery , Thyroid Cancer, Papillary*/surgery , Thyroid Cancer, Papillary*/pathology , Radiofrequency Ablation*/methods , Ultrasonography, Interventional* , Carcinoma, Papillary*/surgery , Carcinoma, Papillary*/pathology , Carcinoma, Papillary*/diagnostic imaging, Humans ; Middle Aged ; Female ; Male ; Adult ; Aged ; Retrospective Studies ; Aged, 80 and over ; Treatment Outcome ; Follow-Up Studies ; Carcinoma/surgery ; Carcinoma/diagnostic imaging ; Carcinoma/pathology
مستخلص: Objective: This study investigates the long-term efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating locally recurrent papillary thyroid cancer (PTC).
Materials and Methods: We retrospectively analyzed 39 consecutive patients with 61 locally recurrent PTCs (14 males, 25 females; mean ± standard deviation age, 52.8 ± 16.7 years; range 21-92 years) who underwent US-guided RFA with curative intent between September 2008 and April 2012. A subgroup of 24 patients with 37 recurrent PTCs who had a follow-up of at least 10 years were analyzed separately. All patients were followed for changes in lesion size on US and thyroglobulin (Tg) levels at 1, 3, 6, and 12 months after RFA, with follow-up every 6-12 months thereafter. Any complications were documented during the follow-up period. Recurrence-free survival (RFS) rates were assessed using Kaplan-Meier estimates. Long-term outcomes were evaluated in patients with follow-up of at least 10 years.
Results: The follow-up period ranged from 7 to 180 months (median 133 months). The RFS rates for the 39 patients at 3, 5, and 10 years were 86.8%, 75.5%, and 60.6%, respectively. Among the 24 patients with 37 recurrent PTCs followed for more than 10 years, the volume reduction rate was 99.9% (range 96%-100%), and the complete tumor disappearance rate was 91.9%. The mean serum Tg level also decreased significantly, from 2.66 ± 86.5 mIU/L before ablation to 0.43 ± 0.73 mIU/L ( P < 0.001) at the final follow-up. In 14 (58.3%) of the 24 patients, Tg levels were undetectable (below 0.08 mIU/L) at the last follow-up. No life-threatening or delayed complications were observed during the 10-year follow-up period.
Conclusion: The high RFS throughout the follow-up period, with efficacy and safety lasting beyond 10 years, supports US-guided RFA as a valuable option for local control of recurrent PTCs.
Competing Interests: Jung Hwan Baek and Jeong Hyun Lee, who hold respective positions as Editorial Board Member and Section Editor of the Korean Journal of Radiology, were not involved in the editorial evaluation or decision to publish this article.
(Copyright © 2024 The Korean Society of Radiology.)
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فهرسة مساهمة: Keywords: Papillary thyroid carcinoma; Radiofrequency ablation; Recurrent thyroid cancer; Treatment outcome; Ultrasound
تواريخ الأحداث: Date Created: 20240828 Date Completed: 20240828 Latest Revision: 20240903
رمز التحديث: 20240903
مُعرف محوري في PubMed: PMC11361795
DOI: 10.3348/kjr.2024.0208
PMID: 39197830
قاعدة البيانات: MEDLINE
الوصف
تدمد:2005-8330
DOI:10.3348/kjr.2024.0208