دورية أكاديمية
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Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.
المؤلفون: García-Muñoz AM; Faculty of Pharmacy and Nutrition, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain., Abellán-Ruiz MS; Faculty of Nursing, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain., García-Guillén AI; Faculty of Medicine, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain., Victoria-Montesinos D; Faculty of Pharmacy and Nutrition, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.
المصدر: Nutrients [Nutrients] 2024 Aug 10; Vol. 16 (16). Date of Electronic Publication: 2024 Aug 10.
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Egg Shell* , Osteoarthritis, Knee*/diagnosis , Osteoarthritis, Knee*/diet therapy, Animals ; Humans ; Dietary Supplements ; Pain Measurement ; Quality of Life ; Randomized Controlled Trials as Topic ; Treatment Outcome
مستخلص: Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review and meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving joint functionality and reducing pain in individuals with knee OA. A comprehensive search was conducted across PubMed, Scopus, Web of Science, and Cochrane Database up to July 2024, following PRISMA guidelines. Seven randomized controlled trials (RCTs) met the inclusion criteria, with five included in the meta-analysis. The studies compared ESM to a placebo, evaluating outcomes based on assessment tools such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results indicated that ESM significantly reduced pain and improved functionality, with notable improvements in total WOMAC score (effect size -0.34; 95% CI: -0.56 to -0.13; p < 0.001) and pain subscale (SMD -0.23; 95% CI: -0.42 to -0.04; p < 0.02). The findings support ESM as a promising adjunctive treatment for knee OA, offering a safe, natural supplement to enhance quality of life. Further high-quality RCTs are needed to confirm these results and explore the long-term effects and mechanisms of ESM.
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فهرسة مساهمة: Keywords: eggshell membrane; joint health; knee pain; nutraceuticals; osteoarthritis
تواريخ الأحداث: Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240913
رمز التحديث: 20240914
مُعرف محوري في PubMed: PMC11356944
DOI: 10.3390/nu16162640
PMID: 39203777
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16162640