دورية أكاديمية
The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives.
| العنوان: | The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives. |
|---|---|
| المؤلفون: | Mohamed W; Basic Medical Science Department, Kulliyyah of Medicine, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.; Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, 3211 Menoufia, Egypt., Eltantawi MA; Department of Neurology, Faculty of Medicine, Delta University for Science and Technology, 11152 Gamasa, Egypt., Agarwal V; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA., Bandres-Ciga S; Centre for Alzheimer's Disease and Related Dementias (CARD), National Institute on Ageing (NIA), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Makarious MB; Centre for Alzheimer's Disease and Related Dementias (CARD), National Institute on Ageing (NIA), National Institutes of Health (NIH), Bethesda, MD 20892, USA.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, WC1N 3BG London, UK., Mecheri Y; Neurology Department, Dr Benbadis University Hospital, 25000 Constantine, Algeria., Zewde YZ; Department of Neurology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Kamel WA; Department of Neurology, Beni-Suef University, 62511 Beni-Suef, Egypt., Al-Mubarak B; King Faisal Specialist Hospital and Research Center, 11564 Riyadh, Saudi Arabia., Alzoubi KH; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, 27272 Sharjah, United Arab Emirates., Kissani N; Department of Neurology, Marrakech Faculty of Medicine and Pharmacy, University Hospital Mohamed VI, 5244 Marrakech, Morocco., Alghamdi BS; Neuroscience and Geroscience Research Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Sassi SB; National Institute Mongi Ben Hmida of Neurology, 1007 Tunis, Tunisia. |
| مؤلفون مشاركون: | AA-PD-GC |
| المصدر: | Journal of integrative neuroscience [J Integr Neurosci] 2024 Aug 19; Vol. 23 (8), pp. 152. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: IMR Press Country of Publication: Singapore NLM ID: 101156357 Publication Model: Print Cited Medium: Internet ISSN: 0219-6352 (Print) Linking ISSN: 02196352 NLM ISO Abbreviation: J Integr Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021-: Singapore : IMR Press Original Publication: London : Imperial College Press, c2002- |
| مواضيع طبية MeSH: | Parkinson Disease*/genetics, Humans ; Genetic Predisposition to Disease |
| مستخلص: | Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community. Competing Interests: Wael Mohamed is serving as one of the Guest editors of this journal. We declare that Wael Mohamed had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Gernot Riedel. The authors declare no conflict of interest. (© 2024 The Author(s). Published by IMR Press.) |
| معلومات مُعتمدة: | ZIAAG000534 Intramural Research Program of the NIH, National Institute on Aging (NIA), National Institutes of Health, Department of Health and Human Services; National Institute of Neurological Disorders and Stroke; MJFF-023995 Michael J Fox Program Genetic Diversity in Parkinson's Disease 2023; Global Parkinson's Genetic Program (GP2) |
| فهرسة مساهمة: | Keywords: AfrAbia; Parkinson's disease; challenges; gaps; genetics; prospects |
| تواريخ الأحداث: | Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240829 |
| رمز التحديث: | 20240902 |
| DOI: | 10.31083/j.jin2308152 |
| PMID: | 39207075 |
| قاعدة البيانات: | MEDLINE |
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