دورية أكاديمية
CD14 is a decision-maker between Fas-mediated death and inflammation.
| العنوان: | CD14 is a decision-maker between Fas-mediated death and inflammation. |
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| المؤلفون: | Magri Z; Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA., Jetton D; Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA., Muendlein HI; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Connolly WM; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Russell H; Graduate Program in Genetics, Molecular & Cellular Biology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA., Smirnova I; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Sharma S; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Bunnell S; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: stephen.bunnell@tufts.edu., Poltorak A; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: alexander.poltorak@tufts.edu. |
| المصدر: | Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114685. Date of Electronic Publication: 2024 Aug 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Lipopolysaccharide Receptors*/metabolism , fas Receptor*/metabolism , Inflammation*/metabolism , Inflammation*/pathology , Signal Transduction* , Macrophages*/metabolism, Animals ; Mice ; NF-kappa B/metabolism ; Apoptosis ; Adaptor Proteins, Vesicular Transport/metabolism ; Mice, Inbred C57BL ; Humans ; Neutrophils/metabolism ; Fas Ligand Protein/metabolism |
| مستخلص: | Signaling through classical death receptor Fas was mainly appreciated as a pro-death pathway until recent reports characterized pro-inflammatory outcomes of Fas-mediated activation in pathological contexts. How Fas signaling can switch to pro-inflammatory activation is poorly understood. Herein, we report that in macrophages and neutrophils, the Toll-like receptor (TLR) adapter CD14 determines the inflammatory output of Fas-mediated signaling. Our findings propose CD14 as a crucial chaperone of Fas receptor internalization in macrophages and neutrophils, resulting in Cd14 -/- myeloid cells that are protected from FasL-induced apoptosis, activate nuclear factor κB (NF-κB), and release cytokines in response. As in TLR signaling, CD14 is also required for Fas to signal through the adaptor TRIF (TIR-domain-containing adapter-inducing interferon-β) and induce a pro-death complex. Our findings demonstrate that CD14 availability can determine the switch between Fas-mediated pro-death and pro-inflammatory outcomes by internalizing the receptor. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | R21 AI176055 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: CD14; CP: Immunology; Fas; TRIF; apoptosis; internalization |
| المشرفين على المادة: | 0 (Lipopolysaccharide Receptors) 0 (fas Receptor) 0 (NF-kappa B) 0 (Adaptor Proteins, Vesicular Transport) 0 (TICAM-1 protein, mouse) 0 (Fas Ligand Protein) 0 (Fas protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240830 Date Completed: 20240926 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| DOI: | 10.1016/j.celrep.2024.114685 |
| PMID: | 39213151 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2024.114685 |