دورية أكاديمية
Influence of selection on the probability of fixation at a locus with multiple alleles.
| العنوان: | Influence of selection on the probability of fixation at a locus with multiple alleles. |
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| المؤلفون: | Overall ADJ; School of Applied Sciences, Huxley Building, University of Brighton, BN2 4GJ, Brighton, East Sussex, UK., Waxman D; Centre for Computational Systems Biology, ISTBI, Fudan University, 220 Handan Road, 200433, Shanghai, People's Republic of China. davidwaxman@fudan.edu.cn. |
| المصدر: | BMC genomics [BMC Genomics] 2024 Aug 30; Vol. 25 (1), pp. 819. Date of Electronic Publication: 2024 Aug 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2000- |
| مواضيع طبية MeSH: | Alleles* , Selection, Genetic* , Models, Genetic* , Probability*, Gene Frequency ; Genetic Loci ; Humans |
| مستخلص: | Background: Genes exist in a population in a variety of forms (alleles), as a consequence of multiple mutation events that have arisen over the course of time. In this work we consider a locus that is subject to either multiplicative or additive selection, and has n alleles, where n can take the values 2, 3, 4, … . We focus on determining the probability of fixation of each of the n alleles. For n = 2 alleles, analytical results, that are 'exact', under the diffusion approximation, can be found for the fixation probability. However generally there are no equally exact results for n ≥ 3 alleles. In the absence of such exact results, we proceed by finding results for the fixation probability, under the diffusion approximation, as a power series in scaled strengths of selection such as R i , j = 2 N e ( s i - s j ) , where N e is the effective population size, while s i and s j are the selection coefficients associated with alleles i and j, respectively. Results: We determined the fixation probability when all terms up to second order in the R i , j are kept. The truncation of the power series requires that the R i , j cannot be indefinitely large. For magnitudes of the R i , j up to a value of approximately 1, numerical evidence suggests that the results work well. Additionally, results given for the particular case of n = 3 alleles illustrate a general feature that holds for n ≥ 3 alleles, that the fixation probability of a particular allele depends on that allele's initial frequency, but generally, this fixation probability also depends on the initial frequencies of other alleles at the locus, as well as their selective effects. Conclusions: We have analytically exposed the leading way the probability of fixation, at a locus with multiple alleles, is affected by selection. This result may offer important insights into CDCV traits that have extreme phenotypic variance due to numerous, low-penetrance susceptibility alleles. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Diffusion analysis; Nearly neutral alleles; Random genetic drift; Selective effect; Stochastic population dynamics |
| تواريخ الأحداث: | Date Created: 20240830 Date Completed: 20240831 Latest Revision: 20240902 |
| رمز التحديث: | 20240902 |
| مُعرف محوري في PubMed: | PMC11365252 |
| DOI: | 10.1186/s12864-024-10733-0 |
| PMID: | 39215209 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2164 |
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| DOI: | 10.1186/s12864-024-10733-0 |