دورية أكاديمية
Identification of risk factors for adverse drug events in a general hospital.
| العنوان: | Identification of risk factors for adverse drug events in a general hospital. |
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| المؤلفون: | Pisetta LM; Department of Pharmacology, Universidade Federal de Santa Catarina (Federal University of Santa Catarina), Campus Trindade, Florianópolis, SC 88049-900, Brazil.; Hospital Santa Isabel, Rede Santa Catarina, Rua Floriano Peixoto 300, Blumenau, SC 89010-906, Brazil., Tonin FZ; Hospital Santa Isabel, Rede Santa Catarina, Rua Floriano Peixoto 300, Blumenau, SC 89010-906, Brazil., Akiyoshi FK; Hospital Santa Isabel, Rede Santa Catarina, Rua Floriano Peixoto 300, Blumenau, SC 89010-906, Brazil., Santos FA; Department of Dentistry, Universidade Estadual de Ponta Grossa (State University of Ponta Grossa), Av. Carlos Cavalcanti 4748, Ponta Grossa, PR 84030-900, Brazil., Fernandes D; Department of Pharmacology, Universidade Federal de Santa Catarina (Federal University of Santa Catarina), Campus Trindade, Florianópolis, SC 88049-900, Brazil. |
| المصدر: | International journal for quality in health care : journal of the International Society for Quality in Health Care [Int J Qual Health Care] 2024 Sep 17; Vol. 36 (3). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9434628 Publication Model: Print Cited Medium: Internet ISSN: 1464-3677 (Electronic) Linking ISSN: 13534505 NLM ISO Abbreviation: Int J Qual Health Care Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Oxford University Press Original Publication: Kidlington, Oxford, UK ; Tarrytown, NY : Pergamon, c1994- |
| مواضيع طبية MeSH: | Drug-Related Side Effects and Adverse Reactions*/epidemiology , Hospitals, General*, Humans ; Cross-Sectional Studies ; Male ; Female ; Retrospective Studies ; Risk Factors ; Middle Aged ; Aged ; Adult |
| مستخلص: | Adverse events (AEs), and particularly adverse drug events (ADEs), represent a health problem as they can cause permanent damage or death. Understanding the frequency, location, and causes of ADEs can prevent harm to patients. The Global Trigger Tool, produced by the Institute for Healthcare Improvement (GTT/IHI), is widely used to identify AEs. Recognizing the profile of patients who suffer ADEs can reveal clinical or individual characteristics that predispose to the occurrence of AEs. A cross-sectional study was carried out through a retrospective analysis of 120 medical charts of patients discharged from hospital between October 2020 and April 2021. Patients over 18 years old, with a length of stay of more than 24 h, were included. The list of triggers used was from the medication module of the GTT/IHI, which was adapted for use in the institution. Two primary reviewers and a medical reviewer applied this tool. The primary reviewers independently assessed the randomized charts. A meeting to achieve consensus among the reviewers was held every 2 weeks to validate the identified ADEs; classifications were based on harm severity. Multivariate logistic regression was utilized to assess the variables that predicted the occurrence of ADEs, using the backward stepwise method. A total of 43 ADEs were identified, with a frequency of 36 per 100 admissions (43/120). Of these, five ADEs (12%) were responsible for patients being admitted to hospital. In the case of in-hospital ADEs, there were 42.2 per 1000 patients/day. The clinical manifestation of altered kidney function (16%) and the anatomical drug group of the nervous system (33%) were the most frequent ADEs. The multivariate logistic regression model was significant (×2 = 44.960, P < .001), indicating that factors such as: known drug allergy [odds ratio 5.728; 95% confidence interval (CI): 1.249, 26.274, P = .025]; being clinically hospitalized (odds ratio 7.504; 95% CI: 1.654, 34.037; P = .009); number of medicines used (odds ratio 1.100; 95% CI: 1.054, 1.148; P < .001); and being under the care of internal medicine (odds ratio 3.633; 95% CI: 1.257, 10.511; P = .017) were predictor variables associated with the occurrence of ADEs. A significant percentage of hospitalized patients experienced at least one ADE, with rates surpassing those found in similar studies. The GTT/IHI effectively assessed medication-related harm, emphasizing the need for tailored triggers based on population characteristics. Predictor variables can inform preventive strategies. Overall, the tool facilitated a localized risk assessment of medication use. (© The Author(s) 2024. Published by Oxford University Press on behalf of International Society for Quality in Health Care. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: adverse drug events; patient harm; patient safety; risk management |
| تواريخ الأحداث: | Date Created: 20240831 Date Completed: 20240917 Latest Revision: 20240917 |
| رمز التحديث: | 20240918 |
| DOI: | 10.1093/intqhc/mzae088 |
| PMID: | 39215969 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3677 |
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| DOI: | 10.1093/intqhc/mzae088 |