دورية أكاديمية
Decellularized Biohybrid Nerve Promotes Motor Axon Projections.
| العنوان: | Decellularized Biohybrid Nerve Promotes Motor Axon Projections. |
|---|---|
| المؤلفون: | Mehta AS; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Zhang SL; Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.; Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 420 E Superior St., Chicago, IL, 60611, USA.; Section for Injury Repair and Regeneration Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.; Department of Pediatrics, Division of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Xie X; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Khanna S; Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA., Tropp J; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Ji X; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Daso RE; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Franz CK; Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.; Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Jordan SW; Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.; Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 420 E Superior St., Chicago, IL, 60611, USA., Rivnay J; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA. |
| المصدر: | Advanced healthcare materials [Adv Healthc Mater] 2024 Sep 01, pp. e2401875. Date of Electronic Publication: 2024 Sep 01. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim : Wiley-VCH, 2012- |
| مستخلص: | Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, biohybrid nerves are developed using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). Nine biohybrid nerves are compared with varying polymerization conditions and cycles, selecting the best candidate through material characterization. These results show that a 1:1 ratio of FeCl (© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.) |
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| معلومات مُعتمدة: | Belle Carnell Regenerative Neurorehabilitation; CCSG P30 CA060553 Northwestern University Center for Advanced Microscopy; NSF ECCS-2025633 Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource; NSF DMR-2308691 Materials Research Science and Engineering Center; N00014-20-1-2777 Office of Naval Research Global; 2023849 Division of Electrical, Communications and Cyber Systems |
| فهرسة مساهمة: | Keywords: bioelectronics; conducting polymers; motor axons; pedot; spinal spheroids |
| تواريخ الأحداث: | Date Created: 20240902 Latest Revision: 20240902 |
| رمز التحديث: | 20240902 |
| DOI: | 10.1002/adhm.202401875 |
| PMID: | 39219219 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2192-2659 |
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| DOI: | 10.1002/adhm.202401875 |