دورية أكاديمية
Anti-thyroid peroxidase antibody in stroke localization: exordium doorway of preliminary findings in thyroidology?
| العنوان: | Anti-thyroid peroxidase antibody in stroke localization: exordium doorway of preliminary findings in thyroidology? |
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| المؤلفون: | Yavuz NC; Giresun University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation - Giresun, Turkey., Seker D; Giresun University, Faculty of Medicine, Department of Neurology - Giresun, Turkey., Sengul D; Giresun University, Faculty of Medicine, Department of Pathology - Giresun, Turkey., Sengul I; Giresun University, Faculty of Medicine, Division of Endocrine Surgery - Giresun, Turkey.; Giresun University, Faculty of Medicine, Department of General Surgery - Giresun, Turkey., Cinar E; Giresun University, Faculty of Medicine, Department of Pathology - Giresun, Turkey., Soares Junior JM; Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Obstetrícia e Ginecologia, Disciplina de Ginecologia, Laboratório de Ginecologia Estrutural e Molecular - São Paulo (SP), Brazil. |
| المصدر: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2024 Sep 02; Vol. 70 (8), pp. e20240447. Date of Electronic Publication: 2024 Sep 02 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo : Associação Médica Brasileira |
| مواضيع طبية MeSH: | Autoantibodies*/blood , Iodide Peroxidase*/immunology, Humans ; Female ; Male ; Middle Aged ; Aged ; Retrospective Studies ; Stroke/immunology ; Stroke/diagnostic imaging ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/immunology ; Ischemic Stroke/blood ; Adult ; Aged, 80 and over ; Risk Factors |
| مستخلص: | Objective: Stroke is a chronic health problem that affects all areas of life. The presence of thyroid autoantibodies can augment the severity of stroke. The aim of this work is to investigate whether there is a relationship between the site of stroke involvement and the anti-thyroid peroxidase antibody (anti-TPO) or not. This is the first study in the English-language literature. Methods: A total of 39 patients with a diagnosis of acute ischemic stroke were included, and the cases under 18 years of age with an infection and the ones with autoimmune diseases other than Hashimoto's thyroiditis were excluded from the study design. The patients' age, gender, smoking status, comorbid conditions, and stroke localization in brain imaging were recorded. The region involving the anterior circulation area originating from the internal carotid artery was evaluated as anterior, and the region possessing the vertebrobasilar circulation area from the vertebral arteries was considered posterior involvement. Thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP), sedimentation, and anti-TPO were retrospectively analyzed. Results: As a consequence, gender distribution, smoking, comorbid conditions, TSH, T3, T4, triglyceride, HDL, LDL, CRP, and sedimentation did not differ significantly, while the age of the posterior-located stroke was lower than that of the cases with the anterior. The anti-TPO value was significantly lower in posterior-located strokes than in the anterior system. Conclusion: In summary, the anti-TPO value was recognized as higher in the anterior stroke localization. Thyroiditis and accompanying anti-TPO autoantibody positivity are conditions that should not be ignored by thyroidologists and thyroid-health providers. |
| References: | Cerebrovasc Dis. 2011;31(1):29-36. (PMID: 20980751) Eur J Neurol. 2014 Jun;21(6):867-73. (PMID: 24602238) Lancet. 1992 Feb 8;339(8789):342-4. (PMID: 1346420) Dis Markers. 2022 Feb 26;2022:8741058. (PMID: 35256895) Cerebrovasc Dis. 2009;28(1):65-71. (PMID: 19468217) Rev Assoc Med Bras (1992). 2022 Jun 24;68(6):721-722. (PMID: 35766679) Rev Assoc Med Bras (1992). 2023 Apr 14;69(4):e20221615. (PMID: 37075449) Clinics (Sao Paulo). 2023 Mar 14;78:100177. (PMID: 36931099) J Assoc Physicians India. 2007 Dec;55:846-50. (PMID: 18405131) J Stroke Cerebrovasc Dis. 2011 Nov;20(6):528-36. (PMID: 21130668) Circ Res. 2018 Oct 26;123(10):1118-1120. (PMID: 30359201) Eur J Nucl Med Mol Imaging. 2004 Dec;31(12):1639-44. (PMID: 15290119) J Clin Endocrinol Metab. 2003 Jun;88(6):2438-44. (PMID: 12788839) Int J Stroke. 2014 Aug;9(6):735-40. (PMID: 24024979) Rev Assoc Med Bras (1992). 2024 Mar 15;70(1):e701EDIT. (PMID: 38511761) J Clin Neurol. 2005 Apr;1(1):14-30. (PMID: 20396469) Cerebrovasc Dis. 2001;11(4):311-6. (PMID: 11385210) Stroke. 2006 Feb;37(2):577-617. (PMID: 16432246) Atherosclerosis. 2019 Jan;280:140-146. (PMID: 30513409) Circulation. 2001 Jul 10;104(2):197-202. (PMID: 11447086) BMC Neurol. 2020 Sep 14;20(1):345. (PMID: 32928146) J Neurol Sci. 2007 Nov 15;262(1-2):60-70. (PMID: 17655871) Clin Endocrinol (Oxf). 2006 Jun;64(6):698-702. (PMID: 16712674) |
| المشرفين على المادة: | 0 (Autoantibodies) EC 1.11.1.8 (Iodide Peroxidase) |
| تواريخ الأحداث: | Date Created: 20240904 Date Completed: 20240904 Latest Revision: 20240912 |
| رمز التحديث: | 20240912 |
| مُعرف محوري في PubMed: | PMC11370745 |
| DOI: | 10.1590/1806-9282.20240447 |
| PMID: | 39230146 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9282 |
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| DOI: | 10.1590/1806-9282.20240447 |