دورية أكاديمية
Gut microbiome and function are altered for individuals living in high fluoride concentration areas in Pakistan.
| العنوان: | Gut microbiome and function are altered for individuals living in high fluoride concentration areas in Pakistan. |
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| المؤلفون: | Bibi S; Department of Biosciences, COMSATS University Islamabad, 45550, Pakistan; Water & Environment Research Group, University of Glasgow, Mazumdar-Shaw Advanced Research Centre, Glasgow G11 6EW, UK., Kerbiriou C; School of Medicine, Dentistry & Nursing, Glasgow Royal Infirmary, Glasgow G31 2ER, UK., Uzma; Water & Environment Research Group, University of Glasgow, Mazumdar-Shaw Advanced Research Centre, Glasgow G11 6EW, UK., Mckirdy S; School of Medicine, Dentistry & Nursing, Glasgow Royal Infirmary, Glasgow G31 2ER, UK., Kostrytsia A; Water & Environment Research Group, University of Glasgow, Mazumdar-Shaw Advanced Research Centre, Glasgow G11 6EW, UK., Rasheed H; National Water Quality Laboratory, Pakistan Council of Research in Water Resources (PCRWR), Islamabad, Pakistan., Eqani SAMAS; Department of Biosciences, COMSATS University Islamabad, 45550, Pakistan., Gerasimidis K; School of Medicine, Dentistry & Nursing, Glasgow Royal Infirmary, Glasgow G31 2ER, UK., Nurulain SM; Department of Biosciences, Grand Asian University Sialkot, Pakistan. Electronic address: syednurulain@gaus.edu.pk., Ijaz UZ; Water & Environment Research Group, University of Glasgow, Mazumdar-Shaw Advanced Research Centre, Glasgow G11 6EW, UK; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 7BE, UK; National University of Ireland, University Road, Galway H91 TK33, Ireland. Electronic address: Umer.Ijaz@glasgow.ac.uk. |
| المصدر: | Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Oct 01; Vol. 284, pp. 116959. Date of Electronic Publication: 2024 Sep 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Netherlands : Elsevier |
| مواضيع طبية MeSH: | Fluorides*/toxicity , Gastrointestinal Microbiome*/drug effects , Drinking Water*/chemistry , Drinking Water*/microbiology , Fluorosis, Dental* , Feces*/microbiology , Feces*/chemistry, Pakistan ; Humans ; Male ; Female ; Adult ; Young Adult ; Water Pollutants, Chemical/analysis ; RNA, Ribosomal, 16S ; Fatty Acids, Volatile/analysis ; Fatty Acids, Volatile/metabolism ; Middle Aged ; Adolescent |
| مستخلص: | Background: Endemic fluorosis refers to the condition when individuals are exposed to excessive amounts of fluoride ion due to living in a region characterized by elevated levels of fluorine in the drinking water, food, and/or air. In Pakistan, a substantial proportion of the population is thereby affected, posing a public health concern. Objectives: Assessing how the gut microbiota and its metabolic profiles are impacted by chronic exposure to fluoride in drinking water (that caused Dental Fluorosis) as well as to perceive how this microbiota is connected to adverse health outcomes prevailing with fluoride exposure. Methods: Drinking water (n=27) and biological samples (n=100) of blood, urine and feces were collected from 70 high fluoride exposed (with Dental Fluorosis) and 30 healthy control (without Dental Fluorosis) subjects. Water and urinary fluoride concentrations were determined. Serum/plasma biochemical testing was performed. Fecal DNA extraction, 16S rRNA analysis of microbial taxa, their predicted metabolic function and fecal short chain fatty acids (SCFAs) quantification were carried out. Results: The study revealed that microbiota taxonomic shifts and their metabolic characterization had been linked to certain host clinical parameters under the chronic fluoride exposure. Some sets of genera showed strong specificity to water and urine fluoride concentrations, Relative Fat Mass index and SCFAs. The SCFAs response in fluoride-exposed samples was observed to be correlated with bacterial taxa that could contribute to adverse health effects. Conclusions: Microbial dysbiosis as a result of endemic fluorosis exhibits a structure that is associated with risk of metabolic deregulation and is implicated in various diseases. Our results may form the development of novel interventions and may have utility in diagnosis and monitoring. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Endemic fluorosis; Gut microbiota; MetaCyc pathways; Short chain fatty acids |
| المشرفين على المادة: | Q80VPU408O (Fluorides) 0 (Drinking Water) 0 (Water Pollutants, Chemical) 0 (RNA, Ribosomal, 16S) 0 (Fatty Acids, Volatile) |
| تواريخ الأحداث: | Date Created: 20240904 Date Completed: 20240928 Latest Revision: 20240928 |
| رمز التحديث: | 20240928 |
| DOI: | 10.1016/j.ecoenv.2024.116959 |
| PMID: | 39232295 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2414 |
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| DOI: | 10.1016/j.ecoenv.2024.116959 |