دورية أكاديمية
أعرض في EDS

Exploring the structural landscape of DNA maintenance proteins.

التفاصيل البيبلوغرافية
العنوان: Exploring the structural landscape of DNA maintenance proteins.
المؤلفون: Schou KB; Genome Integrity, Danish Cancer Institute, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark. kensch@cancer.dk.; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. kensch@cancer.dk.; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Laboratory, Karolinska Institute, Solna, 171 77, Sweden. kensch@cancer.dk., Mandacaru S; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark., Tahir M; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark., Tom N; Lipidomics Core Facility, Danish Cancer Institute (DCI), DK-2100, Copenhagen, Denmark., Nilsson AS; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Laboratory, Karolinska Institute, Solna, 171 77, Sweden., Andersen JS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark., Tiberti M; Cancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark., Papaleo E; Cancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.; Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, 2800, Lyngby, Denmark., Bartek J; Genome Integrity, Danish Cancer Institute, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark. jiri.bartek.1@ki.se.; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Laboratory, Karolinska Institute, Solna, 171 77, Sweden. jiri.bartek.1@ki.se.
المصدر: Nature communications [Nat Commun] 2024 Sep 05; Vol. 15 (1), pp. 7748. Date of Electronic Publication: 2024 Sep 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Protein Domains*, Humans ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Genomic Instability ; Evolution, Molecular ; DNA/chemistry ; DNA/metabolism ; Databases, Protein ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Models, Molecular ; Molecular Sequence Annotation ; Bacteria/genetics ; Bacteria/metabolism
مستخلص: Evolutionary annotation of genome maintenance (GM) proteins has conventionally been established by remote relationships within protein sequence databases. However, often no significant relationship can be established. Highly sensitive approaches to attain remote homologies based on iterative profile-to-profile methods have been developed. Still, these methods have not been systematically applied in the evolutionary annotation of GM proteins. Here, by applying profile-to-profile models, we systematically survey the repertoire of GM proteins from bacteria to man. We identify multiple GM protein candidates and annotate domains in numerous established GM proteins, among other PARP, OB-fold, Macro, TUDOR, SAP, BRCT, KU, MYB (SANT), and nuclease domains. We experimentally validate OB-fold and MIS18 (Yippee) domains in SPIDR and FAM72 protein families, respectively. Our results indicate that, surprisingly, despite the immense interest and long-term research efforts, the repertoire of genome stability caretakers is still not fully appreciated.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 170176 Cancerfonden (Swedish Cancer Society); NNF 20OC0060590 Novo Nordisk Fonden (Novo Nordisk Foundation); CF18-0314 Carlsbergfondet (Carlsberg Foundation)
المشرفين على المادة: 0 (DNA-Binding Proteins)
9007-49-2 (DNA)
0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20240905 Date Completed: 20240905 Latest Revision: 20240910
رمز التحديث: 20240910
مُعرف محوري في PubMed: PMC11377751
DOI: 10.1038/s41467-024-49983-7
PMID: 39237506
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-49983-7