دورية أكاديمية
أعرض في EDS

Factors influencing mortality in intracranial infections caused by carbapenem-resistant Klebsiella Pneumoniae.

التفاصيل البيبلوغرافية
العنوان: Factors influencing mortality in intracranial infections caused by carbapenem-resistant Klebsiella Pneumoniae.
المؤلفون: Lai C; Department of General Practice, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China., Ma Z; Department of General Practice, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China., Luo Y; Department of Neurosurgical Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Luoyg_514@126.com., Gao Y; Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China., Wu Z; Department of Neurosurgical Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China., Zhang J; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450002, China., Xu W; Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
المصدر: Scientific reports [Sci Rep] 2024 Sep 05; Vol. 14 (1), pp. 20670. Date of Electronic Publication: 2024 Sep 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Klebsiella pneumoniae*/drug effects , Klebsiella pneumoniae*/isolation & purification , Klebsiella Infections*/mortality , Klebsiella Infections*/drug therapy , Klebsiella Infections*/microbiology , Carbapenems*/pharmacology , Carbapenems*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Risk Factors ; Retrospective Studies ; Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Adult ; Carbapenem-Resistant Enterobacteriaceae/drug effects ; Carbapenem-Resistant Enterobacteriaceae/isolation & purification
مستخلص: It remains that intracranial infection has an alarming mortality and morbidity. Klebsiella pneumoniae (KP) have increasingly been isolated in ventriculitis and meningitis episodes. Intracranial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) account for high mortality. To understand its clinical impact and related risk factors accurately are crucial in the management of bacterial intracranial infection. The retrospective study aimed to delineate the clinical risk of death from intracranial infection and analyze the risk factors. A total of 176 Klebsiella pneumoniae intracranial infectious patients were available to divide into CRKP group and carbapenem-susceptive Klebsiella Pneumoniae (CSKP) group. We performed survival analysis and estimate the time-varying effects of CRKP and CSKP infection on 30-day mortality. Infectious patients caused by CSKP was associated with lower mortality than CRKP group. The risk factors associated with death from intracranial infection caused by Klebsiella pneumoniae included SOFA scores, ventilator therapy, CRKP, and heart failure. Longer hospital stays are independently associated with lower mortality rates. Intracranial infection caused by CRKP was associated with excess mortality. Complex comorbidities mean higher mortality. Active supportive treatment is required for complicated patients with intracranial infections caused by carbapenem-resistant Klebsiella pneumoniae.
(© 2024. The Author(s).)
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معلومات مُعتمدة: YXKC2021042 Young and Middle-aged Scientific Technological Innovation Jie-Qing Talent Project; SBGJ202102081 Henan Province Key Medical Science and Technology Research Project Co-established by Provincial and Ministerial Authorities (CN); 242102311040 Henan Province Science and Technology Research Project (CN); 242300420384 Henan Province Natural Science Foundation Project (CN)
فهرسة مساهمة: Keywords: Carbapenem-resistant Klebsiella Pneumoniae; Carbapenem-susceptive Klebsiella Pneumoniae; Intracranial infection
المشرفين على المادة: 0 (Carbapenems)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240905 Date Completed: 20240905 Latest Revision: 20240910
رمز التحديث: 20240910
مُعرف محوري في PubMed: PMC11377438
DOI: 10.1038/s41598-024-71660-4
PMID: 39237686
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-71660-4