Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking.

التفاصيل البيبلوغرافية
العنوان:	Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking.
المؤلفون:	Gamal El-Din MI; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Mantawy EM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Said RS; Department of Drug Radiation Research, National Center for Radiation Research & Technology, Egyptian Atomic Energy Authority, Cairo, Egypt., Fahmy NM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Fayez S; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Shahin MI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Nasr M; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Elissawy AM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.; Center for Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt., Singab ANB; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.; Center for Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt.
المصدر:	Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep 06, pp. e2400392. Date of Electronic Publication: 2024 Sep 06.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2005->: Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA Original Publication: Weinheim, Verlag Chemie GmbH.
مستخلص:	Hibiscus species (Malvaceae) possess a plethora of appealing pharmacological activities with an extended history of customary use in diverse medical conditions. The present study aimed at comparing the metabolomic analyses of three Hibiscus species native to Egypt, namely H. tiliaceus, H. schizopetalus extract (HSE), and H. rosa-sinensis, alongside identifying a promising natural wound healing candidate. Chemical profiling of the leaf extracts was achieved via UPLC-ESI/MS/MS-guided analysis that resulted in the tentative identification of a total of 48 secondary metabolites pertaining to phenolic acids, flavonoids, anthocyanins, fatty acids, and fatty amides. Remarkably, in vitro studies revealed that HSE exhibited the topmost wound healing activity. Subsequently, HSE was formulated into hydro- and nanogel (1% w/v) formulations for further assessing its efficacy in the wound excision model. HSE-nanogel demonstrated a significant in vivo wound contraction activity alongside improving histopathological abnormalities. Mechanistically, HSE-nanogel upregulated the wound antioxidant status through increasing the levels of reduced glutathione (GSH) and catalase activity. Moreover, HSE-nanogel suppressed the wound inflammatory responses by diminishing the expressions of NF-ĸB, TNF-α, and IL-6. Molecular docking studies were performed on HSE's major constituents using CDOCKER, which further supported the in vivo findings. Collectively, HSE nanogel exhibits notable aptitude as a wound-healing agent, warranting further clinical appraisal. (© 2024 Deutsche Pharmazeutische Gesellschaft.)
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معلومات مُعتمدة:	46667 Science, Technology and Innovation Funding Authority (STIFA)
فهرسة مساهمة:	Keywords: Hibiscus; LC‐MS; computational studies; inflammation; wound healing
تواريخ الأحداث:	Date Created: 20240906 Latest Revision: 20240906
رمز التحديث:	20240906
DOI:	10.1002/ardp.202400392
PMID:	39240066
قاعدة البيانات:	MEDLINE

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تدمد:	1521-4184
DOI:	10.1002/ardp.202400392