دورية أكاديمية
أعرض في EDS

Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are potentially associated with colorectal cancer susceptibility.

التفاصيل البيبلوغرافية
العنوان: Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are potentially associated with colorectal cancer susceptibility.
المؤلفون: Ijaz M; Institute of Zoology, Bahauddin Zakariya University, Multan, 60800, Pakistan., Chen CC; Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, Taiwan.; Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, 701, Taiwan.; Ph.D. Program in Translational Medicine, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, 40227, Taiwan., Iqbal RK; Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, 60800, Pakistan.; Department of Biology, University of Padova, Padua, Italy., Farooq HA; Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, 60800, Pakistan., Mehmood R; Minar Multan Institute of Nuclear Medicine and Radiology Hospital, Multan, 60800, Pakistan., Asif M; Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, 60800, Pakistan., Akbar A; Department of Statistics, Bahauddin Zakariya University, Multan, 60800, Pakistan., Khan A; Department of Botany and Zoology, Bacha Khan University, Charsadda, 24420, Khyber Pakhtunkhwa, Pakistan., Ijaz W; University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan., Said MB; Laboratory of Microbiology, National School of Veterinary Medicine of Sidi Thabet, University of Manouba, 2010, Manouba, Tunisia. bensaidmourad8@yahoo.fr.; Department of Basic Sciences, Higher Institute of Biotechnology of Sidi Thabet, University of Manouba, 2010, Manouba, Tunisia. bensaidmourad8@yahoo.fr., Wondmie GF; Department of Biology, Bahir Dar University, P.O.Box 79, Bahir Dar, Ethiopia. resercherfent@gmail.com., Ibenmoussa S; Laboratory of Therapeutic and Organic Chemistry, Faculty of Pharmacy, University of Montpellier, 34000, Montpellier, France., Okla MK; Botany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia., Iqbal F; Institute of Zoology, Bahauddin Zakariya University, Multan, 60800, Pakistan. furhan.iqbal@bzu.edu.pk.
المصدر: Scientific reports [Sci Rep] 2024 Sep 03; Vol. 14 (1), pp. 20464. Date of Electronic Publication: 2024 Sep 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Colorectal Neoplasms*/genetics , Polymorphism, Single Nucleotide* , Genetic Predisposition to Disease* , Cytochrome P-450 CYP2E1*/genetics , Fatty Acid-Binding Proteins*/genetics , Tumor Suppressor Protein p53*/genetics, Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Cross-Sectional Studies ; Aged ; Adult ; Pakistan/epidemiology ; Genotype
مستخلص: Colorectal cancer (CRC) is among the most prevalent cancers with a high mortality rate. Both genetic and environmental factors contribute to CRC development. This study aimed to assess the association of single nucleotide polymorphisms (SNPs) in the fatty acid binding protein-2 (rs1799883), Cytochrome P450 2E1 (rs3813865), TP53 (rs1042522), and Murine double minute 2 (rs1042522) genes with CRC. A cross-sectional case-control study was conducted at the Institute of Molecular Biology and Biotechnology from May 2020 to March 2021, involving CRC patients (N = 100) and controls (N = 100) recruited from the Multan district in Pakistan. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) were employed to investigate the studied SNPs. The association of SNPs in all genes with CRC was examined either individually or in various combinations. Genotypes at three SNPs, rs1799883 in FABP2, rs3813865 in CYP2E1, and rs1042522 in TP53, were found to be associated with the development of CRC, while rs1042522 in MDM2 was not. Patients who were married, smoked, lacked exercise habits or had a family history of CRC were at a greater risk of acquiring the disease. FABP2 gene rs1799883, CYP2E1 gene rs3813865, and TP53 gene rs1042522 polymorphisms are significant in the development of CRC in Pakistani participants.
(© 2024. The Author(s).)
References: Mol Biol Rep. 2012 Oct;39(10):9661-8. (PMID: 22744426)
Int J Clin Pract. 2021 Oct;75(10):e14529. (PMID: 34128572)
Diabetes Metab Syndr Obes. 2019 Mar 27;12:413-421. (PMID: 30988637)
J Clin Invest. 1995 Mar;95(3):1281-7. (PMID: 7883976)
Oncol Lett. 2019 Dec;18(6):6807-6821. (PMID: 31788124)
Exp Dermatol. 2018 Dec;27(12):1344-1351. (PMID: 30240097)
J Med Genet. 2005 Sep;42(9):694-8. (PMID: 16141004)
Cancer Epidemiol. 2010 Jun;34(3):291-7. (PMID: 20308031)
PLoS One. 2013 Jun 27;8(6):e67275. (PMID: 23826253)
Nutr Cancer. 2008;60(2):131-44. (PMID: 18444144)
J Pak Med Assoc. 2022 Mar;72(3):457-463. (PMID: 35320225)
J Clin Diagn Res. 2014 Nov;8(11):FC08-10. (PMID: 25584227)
Mutat Res Genet Toxicol Environ Mutagen. 2023 Jan;885:503564. (PMID: 36669813)
Int J Cancer. 2007 Feb 1;120(3):563-5. (PMID: 17096342)
Gene. 2020 Apr 15;734:144391. (PMID: 32001373)
Int J Mol Sci. 2019 Mar 05;20(5):. (PMID: 30841568)
Zhonghua Zhong Liu Za Zhi. 2008 May;30(5):335-8. (PMID: 18953830)
Front Biosci. 2000 Apr 01;5:D424-37. (PMID: 10762600)
J BUON. 2019 May-Jun;24(3):1137-1142. (PMID: 31424672)
Mol Biol Rep. 2021 Aug;48(8):5889-5895. (PMID: 34319543)
Nutrients. 2019 Jun 25;11(6):. (PMID: 31242605)
Sci Rep. 2024 Feb 23;14(1):4459. (PMID: 38396064)
Leukemia. 2020 Nov;34(11):2858-2874. (PMID: 32651541)
Genomics. 2010 Apr;95(4):224-9. (PMID: 20100563)
Asian Pac J Cancer Prev. 2011;12(3):703-8. (PMID: 21627368)
BMC Cancer. 2010 Apr 18;10:147. (PMID: 20398418)
Hum Mutat. 2009 Apr;30(4):661-8. (PMID: 19224585)
Genes (Basel). 2023 Feb 10;14(2):. (PMID: 36833382)
J Cell Biochem. 1997 Mar 1;64(3):343-52. (PMID: 9057092)
Cureus. 2017 Jul 16;9(7):e1477. (PMID: 28944116)
Cancer Genomics Proteomics. 2018 Sep-Oct;15(5):405-411. (PMID: 30194081)
PLoS One. 2016 Sep 29;11(9):e0163421. (PMID: 27684940)
Transl Oncol. 2021 Oct;14(10):101174. (PMID: 34243011)
Cancer Epidemiol. 2017 Aug;49:46-52. (PMID: 28554075)
Asian Pac J Cancer Prev. 2016;17(7):3065-9. (PMID: 27509930)
J Med Genet. 2006 Jun;43(6):531-3. (PMID: 16258005)
Asian Pac J Cancer Prev. 2017 Dec 29;18(12):3423-3427. (PMID: 29286614)
فهرسة مساهمة: Keywords: CYP2E1 gene; Colorectal cancer; FABP2 gene; Genetic polymorphisms; Pakistani population; TP53 gene
المشرفين على المادة: EC 1.14.13.- (Cytochrome P-450 CYP2E1)
0 (Fatty Acid-Binding Proteins)
0 (FABP2 protein, human)
0 (Tumor Suppressor Protein p53)
0 (TP53 protein, human)
تواريخ الأحداث: Date Created: 20240906 Date Completed: 20240906 Latest Revision: 20240914
رمز التحديث: 20240914
مُعرف محوري في PubMed: PMC11379967
DOI: 10.1038/s41598-024-70381-y
PMID: 39242607
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-70381-y