دورية أكاديمية
أعرض في EDS

The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB Pathways.

التفاصيل البيبلوغرافية
العنوان: The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB Pathways.
المؤلفون: Peng Y; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Xiong R; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Wang B; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Chen X; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Ning Y; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Zhao Y; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Yang N; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Zhang J; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Li C; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Zhou Y; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China., Li P; Department of Army Occupational Disease, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), 10 Changjiang Zhilu, Chongqing 400042, People's Republic of China.
المصدر: International journal of biological sciences [Int J Biol Sci] 2024 Aug 19; Vol. 20 (11), pp. 4532-4550. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lake Haven, N.S.W., Australia : Ivyspring International, c2004-
مواضيع طبية MeSH: Wound Healing*/physiology , Wound Healing*/genetics , Receptor, Adenosine A2A*/metabolism , Receptor, Adenosine A2A*/genetics , Mice, Knockout* , Cyclic AMP Response Element-Binding Protein*/metabolism, Animals ; Mice ; Humans ; Endothelial Cells/metabolism ; Neovascularization, Physiologic ; Signal Transduction ; MAP Kinase Signaling System/physiology ; Cell Proliferation/genetics ; Cell Movement/genetics ; Angiogenesis
مستخلص: Adenosine receptor-mediated signaling, especially adenosine A 2A receptor (A 2A R) signaling, has been implicated in wound healing. However, the role of endothelial cells (ECs) in A 2A R-mediated wound healing and the mechanism underlying this effect are still unclear. Here, we showed that the expression of A 2A R substantially increased after wounding and was especially prominent in granulation tissue. The delaying effects of A 2A R knockout (KO) on wound healing are due mainly to the effect of A 2A R on endothelial cells, as shown with A 2A R-KO and EC-A 2A R-KO mice. Moreover, the expression of c-Ski, which is especially prominent in CD31-positive cells in granulation tissue, increased after wounding and was decreased by both EC-A 2A R KO and A 2A R KO. In human microvascular ECs (HMECs), A 2A R activation induced EC proliferation, migration, tubule formation and c-Ski expression, whereas c-Ski depletion by RNAi abolished these effects. Mechanistically, A 2A R activation promotes the expression of c-Ski through an ERK/CREB-dependent pathway. Thus, A 2A R-mediated angiogenesis plays a critical role in wound healing, and c-Ski is involved mainly in the regulation of angiogenesis by A 2A R via the ERK/CREB pathway. These findings identify A 2A R as a therapeutic target in wound repair and other angiogenesis-dependent tissue repair processes.
Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
(© The author(s).)
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فهرسة مساهمة: Keywords: A2AR; Angiogenesis; Endothelial cell; Wound healing; c-Ski
المشرفين على المادة: 0 (Receptor, Adenosine A2A)
0 (Cyclic AMP Response Element-Binding Protein)
تواريخ الأحداث: Date Created: 20240909 Date Completed: 20240909 Latest Revision: 20240910
رمز التحديث: 20240910
مُعرف محوري في PubMed: PMC11380447
DOI: 10.7150/ijbs.98856
PMID: 39247808
قاعدة البيانات: MEDLINE
الوصف
تدمد:1449-2288
DOI:10.7150/ijbs.98856