دورية أكاديمية
أعرض في EDS

Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer.

التفاصيل البيبلوغرافية
العنوان: Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer.
المؤلفون: Evans ET; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Heersink School of Medicine, University of Alabama School of Medicine, Birmingham, Alabama, USA., Page EF; Department of Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Choi AS; Department of Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Shonibare Z; Department of Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Kahn AG; Department of Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Arend RC; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Heersink School of Medicine, University of Alabama School of Medicine, Birmingham, Alabama, USA., Mythreye K; Department of Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
المصدر: Cancer medicine [Cancer Med] 2024 Sep; Vol. 13 (17), pp. e7368.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-
مواضيع طبية MeSH: Carcinoma, Ovarian Epithelial*/pathology , Carcinoma, Ovarian Epithelial*/immunology , Carcinoma, Ovarian Epithelial*/metabolism , Carcinoma, Ovarian Epithelial*/genetics , Carcinoma, Ovarian Epithelial*/mortality , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/immunology , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/mortality , Ovarian Neoplasms*/genetics , Inhibin-beta Subunits*/genetics , Inhibin-beta Subunits*/metabolism , Activins*/metabolism , Activins*/genetics, Humans ; Female ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Middle Aged ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/genetics ; Forkhead Transcription Factors/metabolism ; Forkhead Transcription Factors/genetics
مستخلص: Objective: The TGF-β superfamily member activin, a dimer of the gene products of INHBA and/or INHBB, has been implicated in immune cell maturation and recruitment, but its immune impact within epithelial ovarian cancer (EOC) is not well characterized. We sought to explore differences in activin (INHBA/ Inhibin-βA and INHBB/ Inhibin-βB) between malignant and ovarian tissues at the RNA and protein level and assess the relationship between activin and immune cells in EOC.
Methods: Publicly available RNA sequencing data were accessed from GEO (#GSE143897) with normalization and quantification performed via DESeq2. Immune gene expression profile was further explored within the TCGA-OV cohort derived from The Cancer Genome Atlas (TCGA). Immunohistochemical analysis was performed to evaluate activin A and T-cell markers CD8 and FoxP3 at the protein level. ELISA to activin-A was used to assess levels in the ascites of advanced EOC patients. Kaplan-Meier curves were generated to visualize survival outcomes.
Results: Gene expression levels of components of the activin signaling pathway were elevated within EOC when compared to a benign cohort, with differences in activin type I/II receptor gene profiles identified. Additionally, INHBA gene expression was linked to lymphocytic immune markers in EOC samples. Immunohistochemistry analysis revealed a positive correlation of CD8 and FOXP3 staining with activin A at the protein level in both primary and metastatic epithelial ovarian cancer samples. Furthermore, Activin-A (inhibin-βA) is significantly elevated in EOC patient ascites.
Conclusion: INHBA expression is elevated within EOC, correlating with worse survival, with activin protein levels correlating with specific immune infiltration. Our findings suggest that activin-A may play a role in suppressing anti-tumor immunity in EOC, highlighting its potential as a therapeutic target.
(© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.)
References: N Engl J Med. 2003 Jan 16;348(3):203-13. (PMID: 12529460)
Cancers (Basel). 2019 Aug 26;11(9):. (PMID: 31455033)
Mol Hum Reprod. 2014 Dec;20(12):1223-37. (PMID: 25180271)
J Int Med Res. 2021 Jun;49(6):3000605211014998. (PMID: 34130530)
CA Cancer J Clin. 2021 Jan;71(1):7-33. (PMID: 33433946)
Dev Cell. 2019 May 6;49(3):409-424.e6. (PMID: 31063757)
Prostate. 2011 Jul;71(10):1084-96. (PMID: 21557273)
Sci Signal. 2013 Apr 02;6(269):pl1. (PMID: 23550210)
Anticancer Res. 2017 Jul;37(7):3441-3451. (PMID: 28668833)
Nat Rev Clin Oncol. 2018 May;15(5):325-340. (PMID: 29508855)
PLoS Comput Biol. 2013;9(8):e1003118. (PMID: 23950696)
BJOG. 2000 Sep;107(9):1069-74. (PMID: 11002947)
Cancer Med. 2024 Sep;13(17):e7368. (PMID: 39248018)
Am J Physiol Cell Physiol. 2023 Feb 1;324(2):C428-C437. (PMID: 36622068)
J Cell Physiol. 2019 Aug;234(10):18065-18074. (PMID: 30963572)
Cancers (Basel). 2022 May 06;14(9):. (PMID: 35565437)
Genome Biol. 2021 Nov 29;22(1):323. (PMID: 34844637)
Cell Res. 2017 Jan;27(1):109-118. (PMID: 27995907)
Cancer. 1999 Jan 15;85(2):465-71. (PMID: 10023716)
CA Cancer J Clin. 2022 Jan;72(1):7-33. (PMID: 35020204)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7217-21. (PMID: 3864157)
Br J Cancer. 2012 Nov 20;107(11):1869-75. (PMID: 23169339)
Clin Cancer Res. 2005 Dec 1;11(23):8326-31. (PMID: 16322292)
Biochem Biophys Res Commun. 1985 Jun 14;129(2):396-403. (PMID: 4015638)
Neoplasia. 2009 Apr;11(4):388-96. (PMID: 19308293)
F1000Res. 2015 Dec 30;4:1521. (PMID: 26925227)
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43. (PMID: 16344461)
Cancer Immunol Immunother. 2010 Jun;59(6):909-19. (PMID: 20087581)
Cancer Discov. 2012 May;2(5):401-4. (PMID: 22588877)
Endocr Relat Cancer. 2012 Apr 10;19(2):197-208. (PMID: 22277193)
Cancer Immunol Res. 2021 Jan;9(1):89-102. (PMID: 33093219)
Nature. 1995 Mar 23;374(6520):356-60. (PMID: 7885474)
J Autoimmun. 2019 Nov;104:102314. (PMID: 31416681)
J Biol Chem. 1993 Nov 5;268(31):23066-71. (PMID: 8226823)
Gynecol Oncol. 2018 Oct;151(1):1-3. (PMID: 30243508)
PLoS One. 2021 Apr 5;16(4):e0249558. (PMID: 33819300)
Nucleic Acids Res. 2019 Jan 8;47(D1):D766-D773. (PMID: 30357393)
Sci Rep. 2015 Oct 14;5:15179. (PMID: 26462617)
Mol Cell Biol. 1997 Mar;17(3):1682-91. (PMID: 9032295)
BMC Urol. 2020 May 4;20(1):49. (PMID: 32366240)
J Soc Gynecol Investig. 2004 May;11(4):203-6. (PMID: 15120692)
Br J Cancer. 2011 Oct 11;105(8):1210-7. (PMID: 21897392)
Nat Methods. 2017 Apr;14(4):417-419. (PMID: 28263959)
Ann Surg Oncol. 2010 Jul;17(7):1945-56. (PMID: 20309641)
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7875-80. (PMID: 20385810)
Nat Methods. 2012 Jul;9(7):671-5. (PMID: 22930834)
Gynecol Oncol. 2021 Aug;162(2):421-430. (PMID: 34088514)
Clin Cancer Res. 2022 Apr 1;28(7):1433-1445. (PMID: 35031546)
JAMA Oncol. 2021 Jan 01;7(1):78-85. (PMID: 33211063)
Crit Rev Immunol. 2011;31(1):53-60. (PMID: 21395511)
Ther Adv Med Oncol. 2020 Oct 31;12:1758835920967241. (PMID: 33193829)
J Med Internet Res. 2021 Jul 26;23(7):e27633. (PMID: 34309564)
Clin Cancer Res. 2018 Aug 1;24(15):3717-3728. (PMID: 29666300)
J Immunol. 2009 Apr 15;182(8):4633-40. (PMID: 19342638)
معلومات مُعتمدة: T32 CA229102 United States CA NCI NIH HHS; NCI T32CA229102 Division of Cancer Prevention, National Cancer Institute; NCI R01CA219495 Division of Cancer Prevention, National Cancer Institute
فهرسة مساهمة: Keywords: activin; metastasis; ovarian cancer; tumor immune infiltration
المشرفين على المادة: 93443-12-0 (Inhibin-beta Subunits)
0 (inhibin beta A subunit)
104625-48-1 (Activins)
0 (INHBB protein, human)
0 (activin A)
0 (Biomarkers, Tumor)
0 (Forkhead Transcription Factors)
تواريخ الأحداث: Date Created: 20240909 Date Completed: 20240909 Latest Revision: 20240911
رمز التحديث: 20240911
مُعرف محوري في PubMed: PMC11381957
DOI: 10.1002/cam4.7368
PMID: 39248018
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-7634
DOI:10.1002/cam4.7368