دورية أكاديمية
Relationship Between Infarct Artery, Myocardial Injury, and Outcomes After Primary Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction.
| العنوان: | Relationship Between Infarct Artery, Myocardial Injury, and Outcomes After Primary Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction. |
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| المؤلفون: | de Waha S; Heart Center Leipzig at the University of Leipzig Leipzig Germany.; University Heart Center Lübeck and the German Center for Cardiovascular Research Lübeck Germany., Patel MR; Duke University Medical Center Durham NC., Thiele H; Heart Center Leipzig at the University of Leipzig Leipzig Germany., Udelson JE; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston MA., Granger CB; Duke University Medical Center Durham NC., Ben-Yehuda O; University of California San Diego San Diego CA., Kotinkaduwa L; The Cardiovascular Research Foundation New York NY., Redfors B; The Cardiovascular Research Foundation New York NY., Eitel I; University Heart Center Lübeck and the German Center for Cardiovascular Research Lübeck Germany., Selker HP; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston MA., Maehara A; The Cardiovascular Research Foundation New York NY., Stone GW; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York NY. |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 Sep 17; Vol. 13 (18), pp. e034748. Date of Electronic Publication: 2024 Sep 09. |
| نوع المنشور: | Journal Article; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Percutaneous Coronary Intervention*/adverse effects , Percutaneous Coronary Intervention*/methods , ST Elevation Myocardial Infarction*/therapy , ST Elevation Myocardial Infarction*/surgery , ST Elevation Myocardial Infarction*/diagnostic imaging , Tomography, Emission-Computed, Single-Photon*, Humans ; Male ; Female ; Middle Aged ; Aged ; Treatment Outcome ; Myocardium/pathology ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/pathology ; Randomized Controlled Trials as Topic ; Time Factors ; Risk Factors ; Technetium Tc 99m Sestamibi ; Anterior Wall Myocardial Infarction/therapy ; Anterior Wall Myocardial Infarction/diagnostic imaging ; Anterior Wall Myocardial Infarction/surgery |
| مستخلص: | Background: The extent to which infarct artery impacts the extent of myocardial injury and outcomes in patients with ST-segment-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention is uncertain. Methods and Results: We performed a pooled analysis using individual patient data from 7 randomized STEMI trials in which myocardial injury within 30 days after primary percutaneous coronary intervention was assessed in 1774 patients by cardiac magnetic resonance (n=1318) or technetium-99m sestamibi single-photon emission computed tomography (n=456). Clinical follow-up was performed at a median duration of 351 days (interquartile range, 184-368 days). Infarct size and outcomes were assessed in anterior (infarct vessel=left anterior descending) versus nonanterior (non-left anterior descending) STEMI. Median infarct size (percentage left ventricular myocardial mass) was larger in patients with anterior compared with nonanterior STEMI (19.7% [interquartile range, 9.4%-31.7%] versus 12.6% [interquartile range, 5.1%-20.5%]; P <0.001). Patients with anterior compared with nonanterior STEMI were at higher risk for 1-year all-cause mortality (6.2% versus 3.6%; adjusted hazard ratio [HR], 1.66 [95% CI, 1.02-2.69]; P =0.04) and heart failure hospitalization (4.4% versus 2.6%; adjusted HR, 1.96 [95% CI, 1.15-3.36]; P =0.01). Infarct size was a predictor of subsequent all-cause mortality or heart failure hospitalization in anterior STEMI (adjusted HR per 1% increase, 1.05 [95% CI, 1.03-1.07]; P <0.001), but not in nonanterior STEMI (adjusted HR, 1.02 [95% CI, 0.99-1.05]; P =0.19). The P value for this interaction was 0.04. Conclusions: Anterior STEMI was associated with substantially greater myonecrosis after primary percutaneous coronary intervention compared with nonanterior STEMI, contributing in large part to the worse prognosis in patients with anterior infarction. |
| فهرسة مساهمة: | Keywords: ST‐segment–elevation myocardial infarction; infarct artery; infarct size; microvascular obstruction; prognosis |
| المشرفين على المادة: | 971Z4W1S09 (Technetium Tc 99m Sestamibi) |
| تواريخ الأحداث: | Date Created: 20240909 Date Completed: 20240917 Latest Revision: 20240917 |
| رمز التحديث: | 20240917 |
| DOI: | 10.1161/JAHA.123.034748 |
| PMID: | 39248268 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-9980 |
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| DOI: | 10.1161/JAHA.123.034748 |