دورية أكاديمية
The 2023 South Sudanese outbreak of Hepatitis E emphasizes ongoing circulation of genotype 1 in North, Central, and East Africa.
| العنوان: | The 2023 South Sudanese outbreak of Hepatitis E emphasizes ongoing circulation of genotype 1 in North, Central, and East Africa. |
|---|---|
| المؤلفون: | Orf GS; Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA; Abbott Pandemic Defense Coalition, Abbott Park, IL, USA. Electronic address: gregory.orf@abbott.com., Bbosa N; Abbott Pandemic Defense Coalition, Abbott Park, IL, USA; Uganda Virus Research Institute, Entebbe, Uganda; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda., Berg MG; Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA; Abbott Pandemic Defense Coalition, Abbott Park, IL, USA., Downing R; Abbott Pandemic Defense Coalition, Abbott Park, IL, USA; Uganda Virus Research Institute, Entebbe, Uganda., Weiss SL; Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA; Abbott Pandemic Defense Coalition, Abbott Park, IL, USA., Ssemwanga D; Uganda Virus Research Institute, Entebbe, Uganda; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda., Ssekagiri A; Uganda Virus Research Institute, Entebbe, Uganda., Ashraf S; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., da Silva Filipe A; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Kiiza R; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda., Buule J; Uganda Virus Research Institute, Entebbe, Uganda., Namagembe HS; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda., Nabirye SE; Uganda Virus Research Institute, Entebbe, Uganda., Kayiwa J; Uganda Virus Research Institute, Entebbe, Uganda., Deng LL; National Public Health Laboratory (NPHL), Ministry of Health, Juba, South Sudan., Wani G; National Public Health Laboratory (NPHL), Ministry of Health, Juba, South Sudan., Maror JA; National Public Health Laboratory (NPHL), Ministry of Health, Juba, South Sudan., Baguma A; World Health Organization, Juba, South Sudan; Department of Microbiology, Kabale University School of Medicine, Kabale, Uganda., Mogga JJH; World Health Organization, Juba, South Sudan., Kamili S; Epidemiology and Surveillance Branch, U.S. Centers for Disease Control, Atlanta, GA, USA., Thomson EC; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK; Queen Elizabeth University Hospital, Glasgow, Scotland, UK., Kaleebu P; Uganda Virus Research Institute, Entebbe, Uganda; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda., Cloherty GA; Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA; Abbott Pandemic Defense Coalition, Abbott Park, IL, USA. |
| المصدر: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2024 Oct; Vol. 124, pp. 105667. Date of Electronic Publication: 2024 Sep 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Hepatitis E*/epidemiology , Hepatitis E*/virology , Disease Outbreaks* , Hepatitis E virus*/genetics , Hepatitis E virus*/classification , Phylogeny* , Genotype*, Humans ; South Sudan/epidemiology ; Sudan/epidemiology ; Africa, Eastern/epidemiology ; Genome, Viral ; Bayes Theorem ; Male |
| مستخلص: | In April 2023, an outbreak of acute hepatitis was reported amongst internally displaced persons in the Nazareth community of South Sudan. IgM serology-based screening suggested the likely etiologic agent to be Hepatitis E virus (HEV). In this study, plasma specimens collected from anti-HEV IgM-positive cases were subjected to additional RT-qPCR testing and sequencing of extracted nucleic acids, resulting in the recovery of five full and eight partial HEV genomes. Maximum likelihood phylogenetic reconstruction confirmed the genomes belong to HEV genotype 1. Using distance-based methods, we show that genotype 1 is best split into three sub-genotypes instead of the previously proposed seven, and that these sub-genotypes are geographically restricted. The South Sudanese sequences confidently cluster within sub-genotype 1e, endemic to northeast, central, and east Africa. Bayesian Inference of phylogeny incorporating sampling dates shows that this new outbreak is not directly descended from other recent local outbreaks for which sequence data is available. However, the analysis suggests that sub-genotype 1e has been consistently and cryptically circulating locally for at least the past half century and that the known outbreaks are often not directly descended from one another. The ongoing presence of HEV, combined with poor sanitation and hygiene in the conflict-affected areas in the region, place vulnerable populations at risk for infection and its more serious effects, including progression to fulminant hepatitis. Competing Interests: Declaration of competing interest GSO, SLW, MGB, and GAC are all employees and shareholders of Abbott Laboratories. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Acute hepatitis; Hepatitis E virus; Internally displaced people; Next-generation sequencing; Outbreak; South Sudan |
| تواريخ الأحداث: | Date Created: 20240909 Date Completed: 20240921 Latest Revision: 20240922 |
| رمز التحديث: | 20240922 |
| مُعرف محوري في PubMed: | PMC11413618 |
| DOI: | 10.1016/j.meegid.2024.105667 |
| PMID: | 39251076 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-7257 |
|---|---|
| DOI: | 10.1016/j.meegid.2024.105667 |